Reliability and validity of THINC-it in evaluating cognitive function of patients with bipolar depression

【摘要】：Purpose:The THINC-integrated tool(THINC-it) as a brief screening tool can assesses cognitive impairment in patients with major depressive depression(MDD).We evaluated the reliability and validity of the THINC-it in a bipolar depression(BD-D) group in comparison with a healthy control(HC) group.Materials and Methods:Both groups were matched according to age,gender,years of education and IQ.All participants completed the THINC-it test,including Spotter,Symbol check,Codebreaker,Trails,and the Perceived Deficits Questionnaire for Depression-5-item(PDQ-5-D).The concurrent validity and internal consistency of the THINC-it test were analyzed,and 30 healthy controls were randomly sampled to retest THINC-it to verify the reliability of the THINC-it retest.The correlation between THINC-it and Hamilton Depression Scale(HAMD-17)and Sheehan disability Scale(SDS) was also analyzed.Results:58 patients with BD-D and 61 HC were included for final analysis.There were significant Mean difference(MD) Standard errors(SE) between two groups in PDQ-5-D,Spotter and Codebreaker(all P 0.01),Trails(P=0.015).There was no significant difference in Symbol Check(MD(SE)=-0.01(0.18),P=0.938;95% CI,-0.38 to 0.35).The Cronbach α of PDQ-5-D was 0.640.The Intraclass Correlation Coefficients(ICC) was between0.440 and 0.757.The highest concurrent validity was PDQ-5-D(r=0.812,P 0.001).PDQ-5-D were positively correlated with HAMD-17 and SDS score(P 0.01).The objective test had no significant correlation with HAMD-17 and SDS scores(P 0.05).Conclusion:This study found that THINC-it can accurately present the cognitive impairment of patients with BD-D.It can be potentially applied in assessing the cognitive function of patients with BD-D although Symbol Check may not accurately reflect the level of cognitive function.The concurrent validity and retest reliability are lower than expected,we need to further increase the sample size to study.