收藏本站
收藏 | 手机打开
二维码
手机客户端打开本文

Identification and diagnostic value of pleural fluid periostin and serum periostin of malignant pleural effusions in patients with non-small cell lung cancer

Junjun Wang  Jiali Fu  Qiang Shen  Fan Zhang  Yumin Wang  Lingling Wu  
【摘要】:Background: Data on the diagnostic value of combined detection of pleural fluid periostin(pPOSTN), serum periostin(sPOSTN), pleural effusion carbohydrate antigen 199(pCA199) and pleural effusion adenosine deaminase(pADA) in differentiating malignant pleural effusion(MPE) caused by non-small cell lung cancer(NSCLC) are limited.Methods: We collected 84 pleural effusion samples which including 44 cases of MPE caused by NSCLC and 40 cases of benign pleural effusions(BPE) from August 2018 to January 2019. The pPOSTN, sPOSTN, pleural fluid lactate dehydrogenase(pLDH), pADA, pleural effusion total protein(pTP), pleural fluid glucose(pGLU), pleural effusion leucocyte count(pWBC), pleural effusion red cell count(pRBC), pCA199, pleural fluid carbohydrate antigen 125(pCA125), pleural effusion ferritin(pFer), serum total protein(sTP), serum C-reactive protein(sCRP) were tested, and the obtained data were analyzed by statistical software.Results: The level of pPOSTN in the MPE group was observably lower than the BPE group(Mann-Whitney U=476.000, P=0.000); the level of sPOSTN in the MPE group was observably higher than the BPE group(MannWhitney U=565.500, P=0.005); the sPOSTN/pADA, pCA199/pADA and pCA199/pPOSTN levels in the MPE group were observably higher than the BPE group(Mann-Whitney U=265.000, 259.000 and 282.000, P=0.000, 0.000 and 0.000). The receiver operating characteristic(ROC) curve showed that the area under the ROC curve(AUC)(=0.844, 0.847, 0.841) of sPOSTN/pADA, pCA199/pADA and pCA199/pPOSTN(cutoff=11.86, 0.244, 0.015) were observably higher than other indicators for the diagnosis of MPE caused by NSCLC. Thus, combined detection of pPOSTN, pCA125/pPOSTN and pCA125/sCRP suggested that the AUC, sensitivity and specificity, was 0.912, 95.45% and 77.50% at the cutoff 0.317 and diagnostic performance was higher than sPOSTN/pADA or pCA199/pADA or pCA199/pPOSTN.Conclusion: Combined detection of sPOSTN/pADA, pCA199/pADA and pCA199/pPOSTN can be used a very important index for differentiating MPE caused by NSCLC from BPE with higher diagnostic value than sPOSTN/pADA or pCA199/pADA or pCA199/pPOSTN.

知网文化
【相似文献】
中国期刊全文数据库 前20条
1 Rui Xiao;Qiang Shao;Ning Zhao;Fen Liu;Ke-Jian Qian;;Quantification analysis of pleural line movement for the diagnosis of pneumothorax[J];World Journal of Clinical Cases;2021年21期
2 Marieke De Heer;Robin Cornelissen;Henk C Hoogsteden;Leon M van den Toorn;;Management of recurrent malignant pleural effusions with a tunneled indwelling pleural catheter[J];World Journal of Respirology;2015年02期
3 王玉艳;;Prognosis related clinical and molecular factors in malignant pleural mesothelioma[J];China Medical Abstracts(Internal Medicine);2013年02期
4 Fran?ois Maillet;Nicolas Bonnet;Typhaine Billard-Pomares;Fatma El Alaoui Magdoud;Yacine Tandjaoui-Lambiotte;;Fatal Legionella pneumophila serogroup 1 pleural empyema:A case report[J];World Journal of Critical Care Medicine;2019年06期
5 徐峰,陈杰,沈华浩,王选锭,单江;The diagnostic significance of the detection of cytokeratin 19 mRNA by quantitative RT-PCR in benign and malignant pleural effusions[J];Journal of Zhejiang University Science;2004年10期
6 A BANSAL;S TANDON;S KHARB;;Diagnostic Value of Sialic Acid in Pleural Effusion[J];中国肺癌杂志;2010年04期
7 Xiao-Ting Liu;Xi-Lin Dong;Yu Zhang;Ping Fang;Hong-Yang Shi;Zong-Juan Ming;;Diagnostic value and safety of medical thoracoscopy for pleural effusion of different causes[J];World Journal of Clinical Cases;2022年10期
8 Ya-Ya Hou;Li Peng;Mei Zhou;;Meigs syndrome with pleural effusion as initial manifestation:A case report[J];World Journal of Clinical Cases;2021年21期
9 Nalla NK;Prasad CE;Gopalakrishniah V;Somayajulu VL;Lakshmi K Chelluri;;Adenosine deaminase isoenzymes estimation - as a diagnostic tool for tuberculous pleural effusions[J];Asian Pacific Journal of Tropical Medicine;2009年05期
10 Yong Lu;Hua Lin;Kan Zhai;Xiaojuan Wang;Qiong Zhou;Huanzhong Shi;;Interleukin-17 inhibits development of malignant pleural effusion via interleukin-9-dependent mechanism[J];Science China(Life Sciences);2016年12期
11 Alexander Chi;Sijin Wen;Nam P. Nguyen;Geraldine Jacobson;Scot Remick;William Tse;Zhongxing Liao;;Extra-pleural pneumonectomy in the setting of tri-modality therapy for patients with malignant pleural mesothelioma[J];Chinese Journal of Cancer Research;2013年02期
12 Takashi Anayama;Mai Taguchi;Takehiro Tatenuma;Hironobu Okada;Ryohei Miyazaki;Kentaro Hirohashi;Motohiko Kume;Keisuke Matsusaki;Kazumasa Orihashi;;In-vitro proliferation assay with recycled ascitic cancer cells in malignant pleural mesothelioma: A case report[J];World Journal of Clinical Cases;2019年23期
13 Wei Luan;Wenxin Li;;Safety and efficacy of multi-kinase inhibitor plus endostar treatment in patients with metastatic renal cell carcinoma and pleural effusion[J];Oncology and Translational Medicine;2018年01期
14 ;Delayed internal pancreatic fistula with pancreatic pleural effusion postsplenectomy[J];World Journal of Gastroenterology;2010年35期
15 Guodong Cao;Zhengbo Song;Zhiyi Yang;Zhongjian Chen;Yanjun Hong;Zongwei Cai;;Database-assisted global metabolomics profiling of pleural effusion induced by tuberculosis and malignancy[J];Chinese Chemical Letters;2021年10期
16 Yuki Ishikawa-Kakiya;Hirotsugu Maruyama;Kojiro Tanoue;Shusei Fukunaga;Yasuaki Nagami;Yasuhiro Fujiwara;;Isolated pancreatic metastasis from a malignant pleural mesothelioma diagnosed using endoscopic ultrasonography-guided fne needle aspiration biopsy[J];Hepatobiliary & Pancreatic Diseases International;2022年02期
17 Yi Cheng;Nan Huang;Kai Qin;Jing Zhao;Huihua Xiong;Shiying Yu;Tingting Huang;Qiuyun Guo;;Comparison of intra-pleural injection efficacy between Endostar and Bevacizumab combined with pemetrexed/cisplatin for the treatment of malignant pleural effusion in patients with epidermal growth factor receptor-/anaplastic lymphoma kinase-lung adenocarci[J];Oncology and Translational Medicine;2019年02期
18 Yu Zhang;Li-Ke Yu;Ning Xia;;Evaluation of serum and pleural levels of endostatin and vascular epithelial growth factor in lung cancer patients with pleural effusion[J];Asian Pacific Journal of Tropical Medicine;2012年03期
19 Yang-Tian Chen;Zhi Yang;Huan Li;Chen-Hui Ni;;Clear cell sarcoma of soft tissue in pleural cavity: A case report[J];World Journal of Clinical Cases;2019年19期
20 Greta Saino;Davide Bona;Marco Nencioni;Barbara Rubino;Luigi Bonavina;;Laparoscopic diagnosis of pleural mesothelioma presenting with pseudoachalasia[J];World Journal of Gastroenterology;2009年28期
中国重要会议论文全文数据库 前20条
1 Fang Liu;Shiyi He;Chao Cao;;Clinical significance of pleural effusion eosinophilia: A single-center study and meta analysis[A];2018年(第四十届)浙江省医学会呼吸系病学术年会论文汇编[C];2018年
2 Chuan Shao;Yongwei Guo;Xianfa Xu;Deng Pan;Bijiong Wang;Yaodong Tang;Shuguang Xu;;Non-pyothorax-associated primary pleural lymphoma without pleural effusion in an immunocompetent patient :a case report and literature review[A];2018年(第四十届)浙江省医学会呼吸系病学术年会论文汇编[C];2018年
3 Junjun Wang;Jiali Fu;Qiang Shen;Fan Zhang;Yumin Wang;Lingling Wu;;Identification and diagnostic value of pleural fluid periostin and serum periostin of malignant pleural effusions in patients with non-small cell lung cancer[A];2019年浙江省检验医学学术大会论文汇编[C];2019年
4 Dongwei Hu;;Empyema Caused by Tetratrichomonas: A case report and species identification by phylogenetic analysis[A];2019年浙江省检验医学学术大会论文汇编[C];2019年
5 Wei Xiong;Bin Li;Na Yang;Yuanqian Pu;Zhengliang Li;;Expression and clinical significance of LOXL1 and LOXL2 genes in malignant pleural mesothelioma[A];2021年中国肿瘤标志物学术大会暨第十五届肿瘤标志物青年科学家论坛论文集[C];2021年
6 Ping Sun;Xi-tian Hong;Rui-li Zhang;Yong Shen;Li-li Zhou;Jia-he Sheng;;The value of ER, PR and CA125 expression in breast cancer with pleural effusion patients[A];2017年中国肿瘤标志物学术大会暨第十一届肿瘤标志物青年科学家论坛论文汇编[C];2017年
7 巩若箴;武乐斌;;Computerized tomography pleurography: a new method for detecting minor pleural lesion[A];庆祝山东省医学影像学研究所建所30周年学术论文专刊[C];2005年
8 Feng Wang;Zhaohui Tong;Zhen Wang;Xiaojuan Wang;Lili Xu;Yanbing Wu;;Application of Medical Thoracoscopy in the Diagnosis of Sarcoidosis Pleural Effusion:Cases Study and Retrospective Analysis[A];中华医学会呼吸病学年会——2013第十四次全国呼吸病学学术会议论文汇编[C];2013年
9 Yanghong Peng;;Cervical pleural thickening:a risk factor for endovascular treatment of tuberculosisrelated hemoptysis[A];中华医学会结核病学分会2019年全国结核病学术大会论文汇编[C];2019年
10 Yun-fen Wang;Hong-bin Liu;Yan-wen Yao;Xing-qun Ma;Tang-feng Lv;Dong-mei Yuan;Dong-hong Shi;Yong Song;;Itraconazole suppresses lymphangiogenesis and tumor growth in mice with malignant pleural effusion[A];第13届全国肺癌学术大会论文汇编[C];2013年
11 WanLi Ma;Hong Ye;Qian Zhang;Qing Mu;Jie Yang;Shan-Shan Rao;Feng-Zhi Li;Peng-Cheng Cai;Li-Jun Chen;Jian-Bao Xin;;Bleomycin induced epithelial-mesenchymal transition(EMT) in pleural mesothelial cells[A];中华医学会呼吸病学年会——2013第十四次全国呼吸病学学术会议论文汇编[C];2013年
12 ;CD39+ Regulatory T cells Suppress Generation and Differentiation of Th17 Cells in Malignant Pleural Effusion[A];中华医学会呼吸病学年会——2011(第十二次全国呼吸病学学术会议)论文汇编[C];2011年
13 Mingli Yuan;Huanzhong Shi;Zhaohui Tong;Qiong Zhou;Wanli Ma;Wen Yin;Jianchu Zhang;;Regulation of CD4+ T Cells by Pleural Mesothelial Cells via Adhesion Molecule-Dependent Mechanisms in Tuberculous Pleurisy[A];中华医学会呼吸病学年会——2013第十四次全国呼吸病学学术会议论文汇编[C];2013年
14 Yuan-Sheng Zang;She-Ling Xie;Xue-Wei Zhao;Bing Li;;Specific effects of Arsenic trioxide against experimental lung cancer-associated malignant pleural effusion[A];中华医学会呼吸病学年会——2013第十四次全国呼吸病学学术会议论文汇编[C];2013年
15 ;Th17/Treg imbalance in malignant pleural effusion[A];中华医学会呼吸病学年会——2011(第十二次全国呼吸病学学术会议)论文汇编[C];2011年
16 ZaoXian Mei;Qi Wu Wu;;The Study of Classification Tuberculous Pleurisy Via Flexible Electronic Thoracoscopy[A];中华医学会呼吸病学年会——2013第十四次全国呼吸病学学术会议论文汇编[C];2013年
17 ;Role of Vascular Endothelial Growth Factor and Soluble Intercellular Adhesion Molecule-1on control of pleural effusion and survival in patients with human lung adenocarcinoma[A];中华医学会第五届全国胸部肿瘤及内窥镜学术会议论文汇编[C];2011年
18 程志刚;ZHANG Dezhi;LIANG Ping;YU Xiaoling;HAN Zhiyu;YU Jie;LIU Fangyi;;The clinical value of artificial pleural effusion in assisting ultrasound-guided microwave ablation treatment for hepatic tumors[A];中国超声医学工程学会第三届全国介入超声医学学术会议论文汇编[C];2015年
19 Hiran Fernando;;How Should we Treat Patients Too Sick to Have Anatomic Resection?[A];第四届中国肿瘤学术大会暨第五届海峡两岸肿瘤学术会议教育集[C];2006年
20 GAO Wei-wei;ZHANG Hao;ZHANG Xia;ZHANG Xiang-rong;FANG Gang;DING Huai-ying;DAI Guang-chuan;ZENG Yi;;The advantages of the use of corticosteroids in treatment of TPE:A retrospective clinical study[A];中国防痨协会第32届全国学术大会暨首届中国防痨科技奖颁奖大会论文汇编[C];2018年
中国博士学位论文全文数据库 前1条
1 陆国军;内皮细胞特异性因子-1在非小细胞肺癌相关性恶性胸腔积液中的临床意义[D];南京医科大学;2017年
中国硕士学位论文全文数据库 前6条
1 Hansvin Bunjhoo;[D];华中科技大学;2012年
2 Gopall Roshnee;[D];重庆医科大学;2011年
3 武新舒;恶性胸膜间皮瘤28例临床资料分析[D];山东大学;2016年
4 Arun Kumar Gupta;[D];郑州大学;2007年
5 段美娜;内科胸腔镜对不明原因胸腔积液的诊断价值[D];吉林大学;2017年
6 许晓玲;恶性胸膜间皮瘤6例临床病例分析[D];浙江大学;2010年
 快捷付款方式  订购知网充值卡  订购热线  帮助中心
  • 400-819-9993
  • 010-62982499
  • 010-62783978