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Altered motor-striatal plasticity and cortical functioning in schizophrenia patients

Dongsheng Zhou  Ying Shen  Shiyan Liu  Feng Pang  Lingjiang Liu  Zezhong Fang  Qi Zhou  Xing-xing Li  Chuang Wang  Ti-Fei Yuan  
【摘要】:We have characterized cortical plasticity changes in schizophrenia patients.We findloss of cortical-striatal motor evoked potentials potentiation in these patients when treated with transcranial magnetic stimulation protocols for plasticity induction.Notably,the loss of cortical plasticity wascorrelated to impaired motor learning ability in a rotary pursuit task.Moreover,the loss of plasticity correlates to clinical schizophrenia symptoms in these patients.The results suggest that schizophrenia might lead to altered cortical plasticity and functioning.

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