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Nuclear Genetic Background Determines Respiratory Chain Supercomplex Organization

Dayan Sun  Bin Li  Hao Shi  Fengjie Li  Xiyuan Li  Lijun Shen  Bo Shen  Yanling Yang  Hezhi Fang  Jianxin Lu  
【摘要】:正Respiratory chain complexes are organized into large supercomplexes,among which supercomplexⅠ+Ⅲ_2+Ⅳ_n,is the only supermolecule that can directly transfer electrons from NADH to oxygen.Respiratory supercomplexes have been implicated in human diseases such as cancer and aging because of their role in mitochondrial physiology and biogenesis.Recently,it was reported that the formation of supercomplexⅠ+Ⅲ_2+Ⅳ_n

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