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Proteins in Leaked Amniotic Fluid as Biomarkers Diagnostic for Premature Rupture of Membranes

【摘要】:正Accurate diagnosis of premature rupture of membranes(PROM) remains a clinical challenge.A simple and rapid bedside test would help clinician confirm the diagnosis.We used a protein array to screen cervical-vaginal fluid(CVF) and amniotic fluid samples and found a couple of novel biomarker:soluble intercellular adhesion molecule-1(sICAM-1) and Axl receptor tyrosine kinase(Axl).The mean concentration of these two proteins was 85 and 482 times higher separately in 30 healthy AF samples than in 110 CVF samples of normal pregnancies.The huge concentration difference formed the rationale to use sICAM-1 and Axl as indicators for AF leakage from amniotic cavity to vagina in PROM.In comparing 110 CVF samples of PROM and 110 CVF samples of normal pregnancies,the diagnostic value for PROM was demonstrated by their high sensitivity and specificity(96.4%and 92.7%for sICAM-1,and 92.4%and 90.4%for Axl, respectively),suggesting a rapid immunoassay could be developed using sICAM-1 and/or Axl for clinical diagnosis.

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