Title:Evidence That Estrogens Directly Alter Androgen Regulated genital tubercle(abstract)
【摘要】:正Purpose:The genital tubercle(GT),an anlage of the external genitalia,differentiates into a penis in males and a clitoris in females.From 12.5 days postcoitum(d.p.c.),the embryo GT development show a sexually dimorphic difference between the male and the female,and its initiation and maintenance are androgen-dependent processes.Studies concerning the role of androgens in this period have documented a requirement of 3 factors,