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Hyperammonaemia induces hepatic injury via cell apoptosis with alteration of cyclin A and cyclin D1

Xiaojuan Gao  Zu jiang Yu  Xiao rui Liu  Ran Sun  
【摘要】:正Hepatic failure(HF)is one of the most critical clinical diseases.The mortality rate is as high as 70%80%.The majority patients with Hepatic failure died of a variety of complications,including hepatic encephalopathy,Hepatorenal syndrome,bleeding,etc.Hyperammonemia is thought to be central in the pathophysiology of hepatic encephalopathy in patients suffering from liver failure.Mthough it has been shown that Hyperammonae-

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