A study of population pharmacokinetics of linezolid in Chinese
【摘要】:正OBJECTIVES To analyze the population pharmacokinetic profiles of linezolid in Chinese healthy volunteers and infected patients. METHODS Linezolid 600 mg was administered to Chinese healthy volunteers with single dose and to infected patients every 12 h for at least 5 doses.High performance liquid chromatography was applied to determine the plasma concentration of linezolid.Nonlinear mixed-effects modeling method was applied to analyze the PPK profiles. RESULTS For healthy volunteers with single dose of
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