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Insulin-like Growth Factor 2(IGF2) Potentiates BMP9-induced Osteogenic Differentiation of Mesenchymal Stem Cells and Bone Formation

【摘要】:正Induction of efficient osteogenic differentiation of mesenchymal stem cells(MSCs)may have clinical applications in bone regeneration.We have identified BMP9 as one of the most osteogenic BMPs.Here,we investigate the effect of IGF2 on BMP9-induced bone formation.We have found that endogenous IGF2 expression is low in MSCs.Expression of IGF2 can potentiate

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