The effect of NF-κB dependent JNK signaling pathway In the apoptotlsis and proliferation inhibition induced by intermittent high glucose
【摘要】:正Background:Our previous study found that blocking nuclear factor(NF)-κB signaling could protect human umbilical vein endothelial cells(HUVECs) from apoptosis and proliferation inhibition due to either continuous or intermittentκB pathway on HUVECs induced by intermittent HG(a daily alternating 5.5 or 30.5 mmol/l glucose).high glucose(HG).Intermittent HG makes glucose toxicity more significant.In this study,we further investigate the effect of NF-