Atorvastatin improves effects of transplanted mesenchymal stem cells through amp-activated protein kinase in post-infarcted porcine hearts
【摘要】:正Objective To investigate whether AMP-activated protein kinase (AMPK) involved in the effects of atorvastatin(Ator) improving the effect of BM-MSCs transplantation in treating acute myocardial infarction(AMI). Methods Forty-twoChinese mini-porcine were randomized into 6 groups of sham(n=7),AMI(control;n=7),Ator(atorvastatin;n= 7),MSCs(BM-MSCs transplantation;n=7),Com(combined treatment;re = 7 ) and L-NNA(Ator + MSCs + L-NNA;n=7).Ninty minutes after temporary coronary ligation,animalsin groups of MSCs, Com and L-NNA received autologous BM-MSCs transplantation through intra-myocardial injection into the peri-infarcted areas and followed 4 weeks for functional and structural end points.