Aging exaggerated proliferation of vascular smooth muscle cells is related to attenuation of Jagged1 expression in endothelial cells
【摘要】:正Objective Aging has been shown to enhance the neointimal formation due to abnormal growth of vascular smooth muscular cells(VSMC),which is regulated by endothelial functions.The mechanism of how endothelium affects the growth of VSMC in the process remains unclear.We here examined the role of Jagged1,a regulator for cell growth.Methods and Results Male Sprague-Dawley rats at 3(young) and 22(old) month-old were subjected to a balloon catheter injury in the