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INHIBITORS OF PIGMENTATION IN THE TREATMENT OF HYPERPIGMENTATION DISORDERS

Picardo Mauro  Briganti Stefania  
【摘要】:正The type and amount of melanin synthesized by the melanocytes, and its distribution pattern in the surrounding keratinocytes, determines the actual color of the skin. Melanin is a heterogenous polyphenol - like biopolymer with a complex structure and colors varying from yellow to black. The role of melanin is to protect skin from ultraviolet damage by absorbing UV sunlight and removing reactive oxygen species. Melanin synthesis in mel- anocytic cells is ultimately regulated by tyrosinase a membrane -bound copper- containing glycoprotein,

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