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Therapeutic effects of Tougu Xiaotong capsule may be associated with inhibiting the p38 MAPK pathway mediated inflammation, verifications in vivo and in vitro

Xihai Li  Wenna Liang  Jianwei Zeng  Xiang Shao  Limei Xu  Liangliang Jia  Xiaojuan He  Hui Li  Chunsong Zheng  Hongzhi Ye  
【摘要】:Background: Tougu Xiaotong capsule(TXC) is a Chinese herbal compound, which has been commonly used to treat osteoarthritis(OA) in China. We attempt to verify the therapeutic effects and mechanisms related to p38 MAPK pathway in vivo and in vitro.Methods: The therapeutic effects of TXC were observed by observing cartilage degeneration and inflammatory factors in a modified Hulth's model(in vivo) and a lipopolysaccharides(LPS)-exposed cellular model(in vitro). The expression of biomarkers related to the p38 MAPK pathway mediated inflammation was also investigated.Results: Cartilage degeneration related biomarkers(ADAMTS 4, ADAMTS 5, Col I, Col V, MMP 3, MMP 9 and MMP 13) and inflammation factors(IL-1β, TNF-α and IL-6) in an animal and cellular OA models were reversed by TXC treatments. Expression of p-p38 MAPK were found to be downregulated following TXC administration. Moreover, the changes of miRNAs in cellular models were recovered by TXC. These results indicated that the p38 MAPK pathway-related mechanism may involve in the therapeutic effects of TXC.Conclusions: We further verified the efficacy of TXC to treat OA in vivo and in vitro. The p38 MAPK pathway may play a role in the mechanisms of TXC treatment.

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