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Targeting Candida albicans FLO8 induces protective immunity for inhibiting thymus atrophy during candidiasis

Quan-Zhen Lv  Lan Yan  Yuan-Ying Jiang  Xin-Ming Jia  
【摘要】:正Invasive candidiasis caused by Candida albicans is one of leading death causes among immunocompromised hosts.Morphological switch between yeast and hyphae is critical for C.albicans pathogenesis.The hyphae-deficient form has been associated with triggering protective responses,yet the underlying mechanism remains elusive.In this study,we found that the disruption of C.albicans FLO8,inhibiting yeast-to-hyphae

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