收藏本站
收藏 | 手机打开
二维码
手机客户端打开本文

Improved RP-HPLC method to determine biapenem in human plasma/urine and its application to pharmacokinetic studies

Aidijie Bayasi  
【摘要】:正1 Introduction Biapenem(CAS 120410-24-4) is a carbapenem with antibacterial activity against a broad range of Gram-positive and Gram-negative aerobic and anaerobic bacteria.It is more stable than imipenem,meropenem,and panipenem to hydrolysis by human renal dihydropeptidase-I(DHP-I),and shows comparable antibacterial activity in comparison with other carbapenems,particularly against gram-negative bacteria.In clinical use,the efficiency of biapenem is related to the length of time that the antibiotic concentration remains above the minimum inhibitory concentration(time above MIC). Pharmacokinetic studies can help to establish the optimal dosage regimen for clinical use.

知网文化
【相似文献】
中国重要会议论文全文数据库 前10条
1 Aidijie Bayasi;;Improved RP-HPLC method to determine biapenem in human plasma/urine and its application to pharmacokinetic studies[A];第十二次全国临床药理学学术会议会议论文集[C];2010年
2 ;Determination of moguisteine in human plasma and urine by ESI-LC-MS and its application in pharmacokinetic study[A];中国药理学会第十一次全国学术会议专刊[C];2011年
3 ;Determination of cefazedone in human plasma by high performance liquid chromatography-tandem mass spectrometry:application to a pharmacokinetic study on Chinese volunteers[A];第十二次全国临床药理学学术会议会议论文集[C];2010年
4 ;Quantification of domperidone in human plasma by LC-MS/MS:application to a pharmacokinetic study[A];中国药理学会第十一次全国学术会议专刊[C];2011年
5 ;Determination of thalidomide in human plasma by liquid chromatography-tandem mass spectrometry[A];2011年中国药学大会暨第11届中国药师周论文集[C];2011年
6 ;Proteomic analysis of lipid raft proteins in human endothelial cells after atorvastatin treatment[A];中国生理学会第23届全国会员代表大会暨生理学学术大会论文摘要文集[C];2010年
7 ;A sensitive validated LC-MS-MS method for the quantitation of berberine in human plasma:Application to a pilot pharmacokinetic study in healthy Chinese volunteers[A];合理用药及新药评价专题研讨会日程安排与论文摘要[C];2010年
8 ;Determination of S-propargyl-cysteine in rat plasma by mixed-mode reversed-phase and cation-exchange HPLC-MS/MS method and its application to pharmacokinetic studies[A];第十二次全国临床药理学学术会议会议论文集[C];2010年
9 ;Pharmacokinetics and metabolites of PVP Coated Norcantharidin-Chitosan nanoparticles formulation in rats by LC-MS/MS[A];2011年中国药学大会暨第11届中国药师周论文集[C];2011年
10 ;Determination of thalidomide in human plasma by liquid chromatography-tandem mass spectrometry[A];第十届全国化疗药理暨抗感染药理高峰论坛资料汇编[C];2010年
中国硕士学位论文全文数据库 前3条
1 Camara Mamoudou(马木都);LPS诱导人蜕膜细胞中NF-κB表达的研究[D];中南大学;2011年
2 张杜娟;瑞舒伐他汀与瑞格列奈药物相互作用研究[D];山东大学;2012年
3 孙淑萌;Beagle犬血清中HS203的微量分析及初步药代动力学研究[D];中国海洋大学;2012年
 快捷付款方式  订购知网充值卡  订购热线  帮助中心
  • 400-819-9993
  • 010-62982499
  • 010-62783978