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Effect of Methylamine Irisolidon on Acute Myocardial Ischemia in Anesthetized Dog

【摘要】:正To observe the effect of methylamine irisolidon(8 methylene methylamine iriselidon),a structural modified new compound of kakkalide,which was obtained from Flos Pueraria,on acute myocardial iscehemia in anesthetized dogs.Methods The acute myocardial ischemia model is prepared in dogs by ligating of coronary anterior descending branch.And then observe the effects of methylamine iriselidon intravenously on isehemic area,infarct area, electrocardiogram and myocard zenymogram(including CK-MB、CK、AST、LDH).Results After 240 min of administration, infarct size,normalized by the risk area,in the methylamine irisolidon conditioninggroup was smaller than in the model group (71.51±7.19%in the model group versus(57.90±8.70)% in the test group,P<.01),minifieate the range of myocardial ischemia(N-ST).Myocardial infarct area displayed by the N-BT dyeing is roughly similar with the results measured by the epicardial electrogram,methylamine irisolidon 80 mg·kg~(-1)own the effects of obviously lessening injure in myocardial ischemia, and the infarct area of acute myocardial infarction in anesthetized dog is manifest decreased compared with isehemia model group (P<0.05).The effect of puerarin injection is corresponding with methylamine irisolidon's.Methylamine iriselidon obviously reduces blood serum CK-MB.For CK,there is no statistic meaning,but it has the declining tendency.Conclusion Methylamine iriselidon contributes to the infarct size limitingeffect on acute myocardial ischemia anesthetized dogs.

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