A combined study of genetic association and brain imaging on the DAOA gene in major depressive disorder
【摘要】:正Objective:Compelling evidence suggests that the glutamatergic system may contribute to the pathophysiology of major depressive disorder(MDD).While D-amino acid oxidase activator (DAOA) can affect glutamatergic function,its genetic associations with MDD and abnormal resting state brain activity have yet to be elucidated. Methods:A total of 488 patients with MDD and 480 well-matched controls were recruited to