Temporal and Spatial Dynamics of Rabies Virus in China
【摘要】:正As one of the oldest diseases in the world,rabies history in China can be traced back to 2000 years ago,and for more than a decade,China has been a country with the second highest human rabies cases in the world.Phylogenetic studies have revealed a profound understanding about the biodiversity of rabies virus in China,but the evolutionary dynamics of this virus in the country remain unknown.In present study,the complete G gene sequences of 33 RABVs isolated from distinct provinces of China were determined and phylogenetic analysis was conducted using these G sequences and 91 others retrieved from GenBank representing China and Southeast Asia.Further evolutionary and divergence times of RABV were estimated using a Bayesian Markov chain Monte Carlo method to understand the temporal and spatial dynamics of this virus in China and Asia.Results showed that rabies viruses in China and Southeast Asia share a common ancestor and formed 2 clades,Asian 1 and Asian 2,with each being further divided into 3 lineages.The time of the most recent common ancestor of current RABV variants in China and Southeast Asia was estimated to be year 1762(1648-1859) and the viruses circulating in Southeast Asia likely derived from China.This study presents the first temporal-spatial dynamics of RABV in China and Southeast Asia.