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Neuroprotective and Neurorestorative Strategies in Parkinson's Disease With Antioxidant and Iron Chelating Designed Multimodal Drugs

Moussa B.H. Youdim  
【摘要】:正Parkinson’s (PD) and Lewy Body disease (DLB) are initiated by cascade of neurotoxic events, that includes oxidative stress, brain iron dysregulation, glutamate excitotoxicity, inflammatory process, neurotxic processing misfolding and aggregation of α?synuclein, resulting from the demise of ubiquitin-proteasome system (UPS). PD and DLB

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