Lansoprazole,a Proton Pump Inhibitor,Mediates Anti-inflammatory Effect in Gastrointestinal Tract through the Induction of Heme Oxygenase-1 via Activation of Nrf2 and Oxidation of Keap1

Yuji Naito Tomohisa Takagi Hitomi Okada Takashi Ishii Osamu Handa Satoshi Kokura Hiroshi Ichikawa Hirofumi Matsui Toshikazu Yoshikawa

【摘要】：正[Background] Induction of heme oxygenase-1 (HO-1) expression has been associated with cytoprotective and anti-inflammatory actions of lansoprazole, a proton pump inhibitor, but the underlying molecular mechanisms remain largely unresolved. In this study, we investigate the role of transcriptional factor Nrf2, its phosphorylation/activation, and oxidation of Keap-1 in lansoprazole-induced HO-1 up-regulation using cultured gastric epithelial

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