收藏 | 手机打开

Mitochondrial complex I bridges a connection between regulation of carbon flexibility and gastrointestinal commensalism in the human fungal pathogen Candida albicans

Xinhua Huang  Xiaoqing Chen  Yongmin He  Xiaoyu Yu  Shanshan Li  Ning Gao  Lida Niu  Yinhe Mao  Yuanyuan Wang  Xianwei Wu  Wenjuan Wu  Jianhua Wu  Dongsheng Zhou  Xiangjiang Zhan  Changbin Chen  
【摘要】:Efficient assimilation of alternative carbon sources in glucose-limited host niches is critical for colonization of Candida albicans, a commensal yeast that frequently causes opportunistic infection in human. C. albicans evolved mechanistically to regulate alternative carbon assimilation for the promotion of fungal growth and commensalism in mammalian hosts. However, this highly adaptive mechanism that C. albicans employs to cope with alternative carbon assimilation has yet to be clearly understood. Here we identified a novel role of C. albicans mitochondrial complex I(CI) in regulating assimilation of alternative carbon sources such as mannitol. Our data demonstrate that CI dysfunction by deleting the subunit Nuo2 decreases the level of NAD+, downregulates the NAD+-dependent mannitol dehydrogenase activity, and consequently inhibits hyphal growth and biofilm formation in conditions when the carbon source is mannitol, but not fermentative sugars like glucose. Mannitoldependent morphogenesis is controlled by a ROS-induced signaling pathway involving Hog1 activation and Brg1 repression. In vivo studies show that nuo2Δ/Δ mutant cells are severely compromised in gastrointestinal colonization and the defect can be rescued by a glucose-rich diet. Thus,our findings unravel a mechanism by which C. albicans regulates carbon flexibility and commensalism.Alternative carbon assimilation might represent a fitness advantage for commensal fungi in successful colonization of host niches.

中国期刊全文数据库 前19条
1 André Luis Souza dos Santos;;HIV aspartyl protease inhibitors as promising compounds against Candida albicans[J];World Journal of Biological Chemistry;2010年02期
2 Yujie Zhou;Min Liao;Chengguang Zhu;Yao Hu;Ting Tong;Xian Peng;Mingyun Li;Mingye Feng;Lei Cheng;Biao Ren;Xuedong Zhou;;ERG3 and ERG11 genes are critical for the pathogenesis of Candida albicans during the oral mucosal infection[J];International Journal of Oral Science;2018年01期
3 ;cDNA Array Analysis of the Differential Expression Change in Virulence-related Genes During the Development of Resistance in Candida albicans[J];Acta Biochimica et Biophysica Sinica;2005年07期
4 Tularat Sookto;Theerathavaj Srithavaj;Sroisiri Thaweboon;Boonyanit Thaweboon;Binit Shrestha;;In vitro effects of Salvia officinalis L.essential oil on Candida albicans[J];Asian Pacific Journal of Tropical Biomedicine;2013年05期
5 Xiang-wang Zhao;Lei Yan;Dan Xu;Yu-hui Cui;Chun-hui Yang;Yan-jun Zhou;Jian-guo Tang;;Enterogenous infection of Candida albicans in immunocompromised rats under severe acute pancreatitis[J];World Journal of Emergency Medicine;2016年04期
6 Micheal D. Lafleur;;Fluconazole Susceptibility and Genotypic Heterogeneity of Oral Candida albicans Colonies from the Patients with Cancer Receiving Chemotherapy in China[J];International Journal of Oral Science;2009年03期
7 Kangdi Hu;Wanjie Li;Jiaxin Gao;Qizheng Liu;Haitao Wang;Yue Wang;Jianli Sang;;Role of Ppt1 in multiple stress responses in Candida albicans[J];Chinese Science Bulletin;2014年31期
8 闻建平;李红梅;白静;姜岩;;Biodegradation of 4-Chlorophenol by Candida albicans PDY-07 under Anaerobic Conditions[J];Chinese Journal of Chemical Engineering;2006年06期
9 Jie-hua Deng;Gang-sheng Wang;Ji-hong Li;Xiao-lu Wang;;Effect of cinnamaldehyde on 1,3-β-D-glucans in cell wall of Candida albicans in immunosuppressed BALB/c mice[J];Chinese Herbal Medicines;2018年04期
10 ;Role of CaECM25 in cell morphogenesis, cell growth and virulence in Candida albicans[J];Science in China(Series C:Life Sciences);2008年04期
11 唐欢;魏泓;;Inhibition of germ tube's formation of Candida albicans by lactobacillus spp.[J];Journal of Medical Colleges of PLA;2006年05期
12 Sara D. Altenburg;Sheila M. Nielsen-Preiss;Linda E. Hyman;;Increased Filamentous Growth of Candida albicans in Simulated Microgravity[J];Genomics Proteomics & Bioinformatics;2008年01期
13 Abu Arra Basma;Zakaria Zuraini;Sreenivasan Sasidharan;;A transmission electron microscopy study of the diversity of Candida albicans cells induced by Euphorbia hirta L.leaf extract in vitro[J];Asian Pacific Journal of Tropical Biomedicine;2011年01期
14 ;Genome-wide expression profiling of the response to terbinafine in Candida albicans using a cDNA microarray analysis[J];Chinese Medical Journal;2007年09期
15 Laura Wiebusch;Adriana Araújo de Almeida-Apolonio;Luana Mireli Carbonera Rodrigues;Bruna de Paula Bicudo;Danielly Beraldo dos Santos Silva;Danielle Ferreira Lonchiati;Renata Pires de Araujo;Alexéia Barufatti Grisolia;Kelly Mari Pires de Oliveira;;Candida albicans isolated from urine: Phenotypic and molecular identification,virulence factors and antifungal susceptibility[J];Asian Pacific Journal of Tropical Biomedicine;2017年07期
16 Ghaleb Adwan;Yousef Salameh;Kamel Adwan;;Effect of ethanolic extract of Ecballium elaterium against Staphylococcus aureus and Candida albicans[J];Asian Pacific Journal of Tropical Biomedicine;2011年06期
17 ;Heat-shock protein 90 in Candida albicans[J];Chinese Science Bulletin;2000年06期
18 ;Effects of Two Curcuminoids on Candida albicans[J];Chinese Herbal Medicines;2012年03期
19 ;Intestinal colonization with Candida albicans and mucosal immunity[J];World Journal of Gastroenterology;2004年14期
中国重要会议论文全文数据库 前10条
1 Xinhua Huang;Xiaoqing Chen;Yongmin He;Xiaoyu Yu;Shanshan Li;Ning Gao;Lida Niu;Yinhe Mao;Yuanyuan Wang;Xianwei Wu;Wenjuan Wu;Jianhua Wu;Dongsheng Zhou;Xiangjiang Zhan;Changbin Chen;;Mitochondrial complex I bridges a connection between regulation of carbon flexibility and gastrointestinal commensalism in the human fungal pathogen Candida albicans[A];中国菌物学会第七届全国会员代表大会暨2017年学术年会摘要集[C];2017年
2 逯杨;;Dimorphism in Candida albicans: From Commensal to Pathogen[A];第九届中国模式真菌研讨会摘要集[C];2016年
3 Fabien Cottier;Fritz A.Mühlschlegel;;The transcription factor Fl08 mediates CO_2 sensing in the human fungal pathogen Candida albicans[A];2012年中国菌物学会学术年会会议摘要[C];2012年
4 陈江野;鄢明辉;聂鑫怡;王华峰;高宁;;Sumoylation of Wor1 by a novel SUMO E3 ligase controls cell fate in Candida albicans[A];第十一次全国基因功能与表观遗传调控学术研讨会摘要集[C];2015年
5 常鹏;范雪怡;朱文成;王文娟;吴宏宇;陈江野;;Functional roles and subcellular localization of the subunits in SAGA complex during hyphal development of Candida albicans[A];第十一次全国基因功能与表观遗传调控学术研讨会摘要集[C];2015年
6 曹颖瑛;苗浩;朱臻宇;姜远英;;In vitro activity of shikonin against Candida albicans[A];中国药理学会第十一届全国化疗药理学术研讨会论文集[C];2012年
7 Yuxiao yu;Fei Fu;Xiaoqing Chen;Qiankun Xuan;Lijun Ni;Li Lv;Lihua He;Jian Guo;Guangkun Tan;Wenjuan Wu;;Streptococcus agalactiae Inhibits Hyphal Formation of Candida albicans Independ on Direct Contact[A];中华医学会第十二次全国临床微生物学术年会暨第十一次全球华人临床微生物学与感染症学术年会论文汇编[C];2015年
8 ;Farnesol produced by Candida albicans biofilms and the relation to the resisitance[A];中华口腔医学会第14次全国口腔医学学术会议(2012年会)论文汇编[C];2012年
9 王雄军;朱文成;常鹏;陈江野;;The interplay of chromatin modifier complexes controls cell fate in Candida albicans[A];第十一次全国基因功能与表观遗传调控学术研讨会摘要集[C];2015年
10 ;Antagonistic Interplay of Swi-Snf and Tup1-Ssn6 complexes on Filamentous Growth of Candida albicans[A];2008年全国生物化学与分子生物学学术大会论文摘要[C];2008年
中国硕士学位论文全文数据库 前10条
1 钟罗枫;紫檀芪对白色念珠菌Candida albicans体外抑制作用的初步研究[D];广州中医药大学;2013年
2 李昊典;C.albicans感染中MBL对Treg、Th17表达的影响[D];新乡医学院;2017年
3 张娜;C.albicans感染中MBL浓度改变以及Treg细胞的表达分析[D];新乡医学院;2015年
4 李玲;Candida sp.99-125脂肪酶催化合成人乳脂替代品的研究[D];北京化工大学;2012年
5 李宁;Candida krusei SW 2026羰基还原酶的分离纯化及基因序列研究[D];江南大学;2010年
6 靳颖;对临床分离的90株白假丝酵母菌基因分型和药敏试验研究[D];天津医科大学;2008年
7 Mohamed Jabbie;[D];东北师范大学;2012年
8 徐小琳;Candida Parapsilosis CCTCCM 203011中醇脱氢酶的分离纯化及酶学性质的研究[D];江南大学;2004年
9 裴云芸;Candida rugosa生产脂肪酶的发酵培养基优化及Candida rugosa脂肪酶Lip1的克隆[D];吉林大学;2006年
10 李文霞;脂肪酶Candida sp.99-125催化合成棉籽糖酯[D];北京化工大学;2015年
 快捷付款方式  订购知网充值卡  订购热线  帮助中心
  • 400-819-9993
  • 010-62982499
  • 010-62783978