Methamphetamine abuse impairs motor cortical plasticity and function
【摘要】：Objective Exposure to addictive drugs triggers synaptic plasticity in rewardrelated brain regions, such as the midbrain, nucleus accumbens, and the prefrontal cortex. Effects of chronic drug exposure on other brain areas have not been fully investigated. Methods We characterize synaptic plasticity in motor cortex and dorsal striatum after methamphetamine self-administration in rats. Using transcranial magnetic stimulation(TMS)-induced motor evoked potentials to explore the alteration of plasticity in human patients with methamphetamine addiction. Results(1) Methamphetamine selfadministration causes a loss of cortico-striatal plasticity in rat brain slices and impaired motor learning in the rotarod task.(2) Human patients with addiction performs a lack of TMS-induced potentiation or depression of motor evoked potentials, along with poor performance in rotary pursuit task. Conclusion Chronic methamphetamine use can affect behavioral performance via drug evoked synaptic plasticity occluding physiological motor learning.