基于金属复合物的干扰素传递系统的研究(英文)
【摘要】:正Protein spherulite,a new form of protein aggregation,was prepared for sustained-release of recombinant human interferonα-2b(rhIFN).rhIFN spherulites exhibit good sustained release potential in vitro.Cytopathic inhibition assay was conducted and shown that the spherulitic rhIFN well kept their structural and functional integrity.In vivo studies showed that rhIFN spherulites provided a significantly prolonged PK profile as compared with the soluble rhIFN formulation.
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