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In vivo epidermal migration requires focal adhesion targeting of ACF7

Feng Yang  Hong Liang  
【摘要】:正Turnover of focal adhesions allows cell retraction,which is essential for cell migration.The mammalian spectraplakin protein,ACF7(Actin-Crosslinking Factor 7),promotes focal adhesion dynamics by targeting of microtubule plus ends towards focal adhesions.However,it remains unclear how the activity of ACF7 is regulated spatiotemporally to achieve focal

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