Neuroprotective effects of ligustrazine on hippocampus neurons in PTSD

【摘要】：正Post-traumatic stress disorder(PTSD) is a stress-related mental disorder caused by experience of a traumatic event.PTSD is often accompanied by morphological and functional changes in the hippocampus.The aim of this study was to reveal the neuroprotective effects of Ligustrazine on hippocampus neurons in PTSD rats.Male Sprague Dawley rats(8-9 weeks old and 200-220 g)were exposed to SPS(single prolongd stress).The SPS rats were randomly divided into two groups:SPS group and Ligustrazine treated group.The Ligustrazine treated group were intraperitoneal(i.p.) injection of Ligustrazine(50 mg/kg) once daily for 10 days.The SPS group were intraperitoneal(i.p.) injection with saline of the same dose at the same time Open field test,Morris water maze and brdu Immunohistochemical staining were used to detect the changes of behaver and Hippocampus neurogenesis.Our results showed that Ligustrazine can significantly improve the behavioral performance and increase Hippocampus neurogenesis.The present findings suggest that Ligustrazine has a beneficial influence on PTSD.