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Total Synthesis and Determination of the Absolute Configuration of Rakicidin A

Feng Sang  Dongmei Li  Xiaolong Sun  Xianqiang Cao  Liang Wang  Jianlei Sun  Bingxia Sun  Lingling Wu  Guang Yang  Xiaoqian Chu  Jinghan Wang  Changming Dong  Yan Geng  Hong Jiang  Haibo Long  Sijia Chen  Guiyan Wang  Shuzhong Zhang  Quan Zhang  Yue Chen  
【摘要】:正Rakicidin A is a cyclic epsipeptide that has exhibited unique growth inhibitory activity against chronic myelogenous leukemia stem cells.Furthermore,rakicidin A has five chiral centers with unknown stereochemical assignment,and thus,can be represented by one of 32 possible stereoisomers.To predict the most probable stereochemistry of rakicidin A,calculations and structural comparison with natural cyclic depsipeptides were applied.A total synthesis of the

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