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Targeted therapy for cancer:from protein modification and degradation to medication

【摘要】:正Protein modification and degradation play critical roles in cell cycle progression, transcriptional regulation, DNA repair, apoptosis, immune response, and protein quality control. Aberrations in these processes can lead to diseases including cancer, while strategies overcoming the abnormalities have been shown to be novel therapeutics. The proteasome inhibitor Bortezomib, which inhibits proteasomal degradation of IκB

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