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A Practical and Controllable Enantioselective Synthesis of 2-Phenyl-1-cyclopropanecarboxylates via Camphor-derived Sulfonium Ylide

黄志真  黄坤  
【摘要】:正Optically active 2-phenyl-l-cyclopropanecarboxy-lates are very useful intermediates in the synthesis of chiral compounds. However, only one report appeared from the literature on the enantioselective synthesis of 2-phenyl-1-cyclopropanecarboxlates via ylides routes. In this protocol, chiral sulfide is prepared from expensive (R)-Pulegone only in 30% yield. And the reaction of the sulfide with aliphatic bromide does not occur unless in the presence of ex-

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