收藏 | 手机打开

Association of prenatal maternal cortisol with adiposity and cardiometabolic outcomes in early childhood

Shaowei Wu  Robert O.Wright  Elena Colicino  Heather H.Burris  Allan C.Just  Joseph M.Braun  Katherine Svensson  Kasey J.M.Brennan  Alexandra Dereix  Alejandra Cantoral  Lourdes Schnaas  Martha Maria Téllez-Rojo  Andrea A.Baccarelli  Rosalind J.Wright  
【摘要】:Objectives Disturbance in the hypothalamic-pituitary-adrenal(HPA)-axis function may program childhood obesity and cardiometabolic phenotypes.We investigated whether prenatal Cortisol was associated with childhood adiposity and cardiometabolic phenotypes.Methods We characterized maternal HPA-axis function using 10 timed salivary Cortisol measurements collected over two days during pregnancy in 552 mothers from Mexico City,Mexico.We measured child anthropometric and cardiometabolic phenotypes at 4-6 years of age.Body mass index(BMI) z-scores were calculated according to World Health Organization reference.Generalized linear regression models were used to evaluate the association between maternal Cortisol variables and adiposity and cardiometabolic outcomes controlling for other potential confounders.Results In multivariable-adjusted models,an interquartile range(IQR) increase in area under curve(AUC) of prenatal Cortisol(4.0) was associated with increases of0.13 unit(95%CI:0.02,0.24) in BMI z-score,3.1%(95%CI:0.2,6.1) in body fat mass(BFM) and 2.4%(95%CI:0.3,4.5) in percentage body fat(PBF) among all children.There were significant interactions between maternal Cortisol at time 5 and PM slope and child sex on adiposity and cardiometabolic outcomes(i.e.,blood pressure and leptin).An IQR in maternal Cortisol at time 5(3.0 μg/dl) was associated with decreases of-0.09 unit(95%CI:-0.19,0.02) in BMI z-score,3.0%(95%CI:-6.2,0.4) in BFM,1.8%(95%CI:-4.3,0.8) in PBF and 0.5%(95%CI:-1.3,0.2) in waist circumference among boys;but increases of 0.10 unit(95%CI:0.01,0.19) in BMI z-score,2.7%(95%CI:-0.7,6.3) in BFM,1.7%(95%CI:-0.6,4.0) in PBF and 0.8%(95%CI:-0.05,1.7) in waist circumference among girls(p=0.003,0.02,0.045 and0.02 for interactions).Conclusion Prenatal Cortisol was associated with childhood adiposity and cardiometabolic outcomes among in a Mexican cohort,and there were significant sex-specific differences.

中国期刊全文数据库 前20条
1 Jin-Uk Lee;Okjin Kim;;Natural maternal transmission of H pylori in Mongolian gerbils[J];World Journal of Gastroenterology;2006年35期
2 ;Comparison of infection frequencies in fetus by maternal ascitic cancer and leukemia cells[J];Chinese Science Bulletin;1998年10期
3 Guohui Zhang;Yunan Zhao;Xin-Min Li;Jiming Kong;;Fetal cell microchimerism in the maternal mouse spinal cord[J];Neuroscience Bulletin;2014年01期
4 Kenichi Nomura;Yoshio Sumida;Takaharu Yoh;Atsuhiro Morita;Yosuke Matsumoto;SawakoTaji;NaohisaYoshida;MasahitoMinami;YoshitoItoh;ShigeoHoriike;Keisho Kataoka;Masafumi Taniwaki;Takeshi Okanoue;;Lack of evidence for leukocyte maternal microchimerism in primary biliary cirrhosis[J];World Journal of Gastroenterology;2004年16期
5 Lv Yanqiu;;Monitoring Report of Maternal Antibody of Broiler Avian Influenza Virus H5 Subtype Re-8 Strain[J];Animal Husbandry and Feed Science;2017年06期
6 Ekabua JE;Agan TU;Iklaki CU;Ekabua KJ;Etokidem AJ;;Risk of adverse maternal outcome following macrosomic birth in Nigeria.[J];海南医学院学报;2010年01期
7 ;Risk factors and long-term health consequences of macrosomia:a prospective study in Jiangsu Province,China[J];Journal of Biomedical Research;2012年04期
8 Heju Zhong;Hao Li;Guangmang Liu;Haifeng Wan;Yves Mercier;Xiaoling Zhang;Yan Lin;Lianqiang Che;Shengyu Xu;Li Tang;Gang Tian;Daiwen Chen;De Wu;Zhengfeng Fang;;Increased maternal consumption of methionine as its hydroxyl analog promoted neonatal intestinal growth without compromising maternal energy homeostasis[J];Journal of Animal Science and Biotechnology;2017年01期
9 ;Second-trimester maternal β-human chorionic gonadotropin level associated with subsequent development of pregnancy-induced hypertension[J];Journal of Medical Colleges of PLA;2010年05期
10 ;母亲怀孕过程中饮酒与儿童急性白血病关系的Meta分析(英文)[J];Chinese-German Journal of Clinical Oncology;2010年08期
11 KAZUHITO YOKOYAMA;;Maternal and Fetal Exposure to Four Carcinogenic Environmental Metals[J];Biomedical and Environmental Sciences;2010年06期
12 Marlúcia Bastos Aires;Anne Carolline Veríssimo dos Santos;;Effects of maternal diabetes on trophoblast cells[J];World Journal of Diabetes;2015年02期
13 吴军,刘棣临,周建德;ZINC DEPLETION IN SEVERE PRE-ECLAMPSIA[J];Journal of Shanghai Second Medical University;1987年02期
14 ;Woman Breast-Feeds Baby[J];Women of China;1995年07期
15 于琼;管群;李萍;刘铁兵;司峻峰;肇莹;刘红星;王元庆;;Wavelet optimization for applying continuous wavelet transform to maternal electrocardiogram component enhancing[J];Chinese Physics B;2017年11期
16 Osman Demirhan;Necmi ekin;Deniz Tastemir;Erdal Tun;Ali rfan Güzel;Demet Meral;Bülent Demirbek;;Are there fetal stem cells in the maternal brain?[J];Neural Regeneration Research;2013年07期
17 ;Analysis of seed and maternal genetic effects on cooking quality characters in indica hybrid rice[J];Chinese Rice Research Newsletter;1994年03期
18 Nam-Joon Yi;Min-Su Park;Eun Young Song;Hye Young Ahn;Jeik Byun;Hyeyoung Kim;Suk Kyun Hong;Kyungchul Yoon;Hyo-Sin Kim;Sung-Woo Ahn;Hae Won Lee;Young Rok Choi;Kwang-Woong Lee;Kyung-Suk Suh;Myoung Hee Park;;Pretransplantation fetal-maternal microchimerism in pediatric liver transplantation from mother[J];World Journal of Gastroenterology;2017年45期
19 ;A new statistical method for mapping QTLs underlying endosperm traits[J];Chinese Science Bulletin;2005年14期
20 华嘉增;CURRENT STATUS OF MATERNAL HEALTH CARE IN CHINA[J];Chinese Medical Journal;1994年05期
中国重要会议论文全文数据库 前10条
1 Shaowei Wu;Robert O.Wright;Elena Colicino;Heather H.Burris;Allan C.Just;Joseph M.Braun;Katherine Svensson;Kasey J.M.Brennan;Alexandra Dereix;Alejandra Cantoral;Lourdes Schnaas;Martha Maria Téllez-Rojo;Andrea A.Baccarelli;Rosalind J.Wright;;Association of prenatal maternal cortisol with adiposity and cardiometabolic outcomes in early childhood[A];2018环境与健康学术会议--精准环境健康:跨学科合作的挑战论文汇编[C];2018年
2 ;Selection for increased maternal body-volume does not differ between two Scincella lizards with different reproductive modes[A];第七届全国野生动物生态与资源保护学术研讨会论文摘要集[C];2011年
3 ;Effects of maternal treatment of dehydroepiandrosterone(DHEA)on serum lipid profile and hepatic lipid metabolismrelated gene expression in embryonic chickens[A];全国动物生理生化第十一次学术交流会论文摘要汇编[C];2010年
4 Gang Wang;Tianxiao Hu;Baozhen Zhang;Xin Ni;;Dysregulation of placental 11β-hydroxysteroid dehydrogenase type 2 contributes to maternal hypertension,renal damage and abnormal placentation in preeclampsia[A];中国生理学会生殖科学专业委员会—中国动物学会生殖生物学分会第二次联合学术年会暨“生殖科学专业委员会第二次学术交流会”和“生殖生物学分会第十六次学术年会”论文集[C];2017年
5 Dandan Qin;Xiaoxin Zhang;Zheng Gao;Yi Xiao;Lei Li;;NLRP4F,a novel component of the subcortical maternal complex,is involved in mouse maternal to zygotic transition[A];中国生理学会生殖科学专业委员会—中国动物学会生殖生物学分会第二次联合学术年会暨“生殖科学专业委员会第二次学术交流会”和“生殖生物学分会第十六次学术年会”论文集[C];2017年
6 高军;;Roles of Serotonin 5-HT2A Receptors and Its Interaction with Dopamine D2 Receptors in Maternal Behavior in Rats: Implications for Postpartum Mental Disorders[A];第二十届全国心理学学术会议--心理学与国民心理健康摘要集[C];2017年
7 Li-su Huang;;MATERNAL CHRONIC STRESS AND FETAL SEX RATIO[A];2012年江浙沪儿科学术年会暨浙江省医学会儿科学分会学术年会、儿内科疾病诊治新进展国家级学习班论文汇编[C];2012年
8 Youshang Zhao;Songyun Wang;Wenye Wu;Lei Li;Ting Jiang;Binglian Zheng;;Clearance of maternal barriers by paternal miR159 to initiate endosperm nuclear division in Arabidopsis[A];2018全国植物生物学大会论文集[C];2018年
9 ;Maternal Effects on Seed Oil Content in Brassica napus[A];第十二届全国植物基因组学大会论文集[C];2011年
10 Yanhong L;Di Zhang;Yu Tao;Songcun Wang;Yuanyuan Xu;Hailan Piao;Dajin Li;Meirong Du;;Tim-3-expressing NK cells in the peripheral blood promotes maternal-fetal immune tolerance and prevents pregnancy loss[A];中国生理学会生殖科学专业委员会—中国动物学会生殖生物学分会第二次联合学术年会暨“生殖科学专业委员会第二次学术交流会”和“生殖生物学分会第十六次学术年会”论文集[C];2017年
中国博士学位论文全文数据库 前2条
1 爱莎(Ccamara Aissata Kandet);[D];华中科技大学;2013年
2 Mahmoud Ahmed Suliman Ali;[D];重庆大学;2012年
中国硕士学位论文全文数据库 前10条
1 Maria Jose Gonzalez Mendez;SSA地区国家MMR的差异和影响因素分析[D];大连医科大学;2018年
2 MABINDRA SHRESTHA;[D];重庆医科大学;2017年
3 Augustine F.Tokpa;[D];华中科技大学;2012年
4 Samira Bomposseh Alim Sesay;[D];郑州大学;2018年
5 杨晓娜;母性神话的颠覆[D];内蒙古大学;2014年
6 韩艳丽;托尼·莫里森小说中的黑人母爱主题的研究[D];内蒙古大学;2011年
7 Sarah Chiwamba;幼儿教育阶段教与学方法的比较研究[D];东北师范大学;2011年
8 汤涟漪;追寻真正的童真[D];中国矿业大学;2015年
9 SUCHI DWIVEDI;[D];昆明医科大学;2013年
10 Ramji Yadav;[D];昆明医科大学;2013年
 快捷付款方式  订购知网充值卡  订购热线  帮助中心
  • 400-819-9993
  • 010-62982499
  • 010-62783978