收藏本站
收藏 | 论文排版

Mouse Lymphoma Assay Validation under New OECD Guideline TG490 in WuXi AppTec

Millie Chen  Liwen Gao  Yunlan Guo  
【摘要】:正[Purpose]The mouse lymphoma assay(MLA)is the most widely used mammalian cell gene mutation assay for regulatory purposes and is included in the core battery of genotoxicity tests for the registration of pharmaceuticals,medical devices and for other regulatory decision-making.Most clients in WuXi AppTec(Suzhou)request to do the chromosome aberration assay instead of MLA to file their IND package,however,MLA has

知网文化
【相似文献】
中国期刊全文数据库 前16条
1 ;EVALUTION OF CHINESE MEDICINE COMPOUND SHOU WU FOR MUTAGENIC AND ANTIMUTAGENIC ACTIVITIES BY TWO DIFFERENT GENETIC SYSTEMS[J];癌变.畸变.突变;1991年S1期
2 ;MUTAGENICITY ASSAY OF CIPROFLOXACIN(cipro)[J];癌变.畸变.突变;1991年S1期
3 ;CROSS-RESISTANCE INDUCED BY LOW DOSEX-RAYS OR LOW CONCENTRATION OF MMCIN SOMATIC AND GERM CELLS[J];白求恩医科大学学报;1992年01期
4 Eun-HoPark,Youn BongOh,Jae-SeongLee,MyoungSookYi.;INDUCTION OF CHROMOSOMAL ABERRATIONS BY DIRECT ACTING MUTAGENS IN FISH CELL LINE ULF-23HU[J];癌变.畸变.突变;1991年S1期
5 ;Experimental St■■■es on the Mutagenicity of Hydroxypiperaquine Phosphate[J];Journal of Medical Colleges of PLA;1989年01期
6 ;THE INFLUENCE OF ZINC ON THE MUTAGENICITY OF CADMIUM[J];癌变.畸变.突变;1991年S1期
7 ;Contrast sensitivity and higher-order aberrations in patients with astigmatism[J];Chinese Medical Journal;2007年10期
8 Liexi Jia;Zhaohui Li;;Evaluation of the Consistency of Total Spherical Aberration before and after Aspherical Intraocular Lens Implantation[J];Eye Science;2013年03期
9 Seyed Javad Hashemian;Mohammad Soleimani;Alireza Foroutan;Mahmood Joshaghani;Mohammad Jafar Ghaempanah;Mohammad Ebrahim Jafari;Mehdi Yaseri;;Ocular higher-order aberrations and mesopic pupil size in individuals screened for refractive surgery[J];International Journal of Ophthalmology(English Edition);2012年02期
10 ;Statistical virtual eye model based on wavefront aberration[J];International Journal of Ophthalmology(English Edition);2012年05期
11 Manu Chaudhary;Anurag Payasi;;Evaluation of genotoxicity of Trois through Ames and in vitro chromosomal aberration tests[J];Asian Pacific Journal of Tropical Biomedicine;2013年11期
12 于靖;陈佚卉;陈辉;盛敏杰;;EFFECT OF SHORT-TERM SOFT CONTACT LENS WEAR ON HUMAN OCULAR ABERRATIONS[J];Journal of Shanghai Second Medical University(Foreign Language Edition);2009年02期
13 DIPANWITA DUTTA;S.SARAVANA DEVI;K.KRISHNAMURTHI;KOEL KUMAR;PRIYANKA VYAS;P.L.MUTHAL;P.NAOGHARE;T.CHAKRABARTI;;Modulatory Effect of Distillate of Ocimum sanctum Leaf Extract (Tulsi) on Human Lymphocytes Against Genotoxicants[J];Biomedical and Environmental Sciences;2007年03期
14 DIPANWITA DUTTA;S. SARAVANA DEVI;K. KRISHNAMURTHI;T. CHAKRABARTI;;Anticlastogenic Effect of Redistilled Cow's Urine Distillate in Human Peripheral Lymphocytes Challenged With Manganese Dioxide and Hexavalent Chromium[J];Biomedical and Environmental Sciences;2006年06期
15 ;DISEASE CAUSED BY CHEMICAL AND PHYSICAL AGENTS[J];China Medical Abstracts(Internal Medicine);1997年01期
16 ;[J];;年期
中国重要会议论文全文数据库 前5条
1 ;Two level FFSP designs with weak minimum aberration[A];中国现场统计研究会第12届学术年会论文集[C];2005年
2 曹信芳;沈晔;;The relationship between wavefront aberration and the optic tilt after ICL implantation[A];2011年浙江省眼科学术会议论文集[C];2011年
3 ;Minimum aberration Majorization in non-isomorphic saturated asymmetric designs[A];2007均匀试验设计学术交流会论文集[C];2007年
4 David Santiago;;Asphericity,Spherical Aberration and Ablation Innovation[A];中华医学会第十二届全国眼科学术大会论文汇编[C];2007年
5 Yash Pal;;研究型大学全球合作项目(英文)[A];北京论坛(2008)文明的和谐与共同繁荣——文明的普遍价值和发展趋向:“国际合作与发展”教育分论坛论文或摘要集[C];2008年
 快捷付款方式  订购知网充值卡  订购热线  帮助中心
  • 400-819-9993
  • 010-62982499
  • 010-62783978