EFFECTS OF Ku70-DEFICIENT ON ARSENITE-INDUCED DNA DOUBLE STRAND BREAKS, CHROMOSOMAL ALTERATIONS AND CELL CYCLE ARREST
【摘要】:正As one of three subunits of DNA-dependent protein kinase (DNA-PK), Ku70 protein plays important role in repairing DNA double-strand breaks (DNA DSBs). Arsenic is a known human carcinogen. To further understand the functions of Ku70 protein and the mechanisms of arsenite-induced genetoxicity, we have studied the effects of Ku70-deficiency on arsenite-induced genotoxicity. The