A clinical study on double-unit umbilical cord blood transplantation in adults with hematologic disease
【摘要】:正Objective:In this study,we explored the efficiency and toxicity of 46 cases of double-unit CBT in adults with hematologic disease. Methods:The tolerance;transplant related complications; survival rate and disease free survival rate were observed and analyzed.A nonmyeloablative conditioning regimen included cyclophosphamide,fludarabine and 2Gy TBI. Cyclosporine combined mycophenolate mofetil and ATG were used to prevent graft versus host disease(GVHD). Results:All these 46 patients tolerated the therapy well while four patients had graft failure.Severe acute GVHD was presented in 6 patients.Chronic GVHD was occurred in 18 patients.Fatal infection complications were occurred