Role of angiogenic factor Cyr61 in migration and tube formation of endothelial progenitor cells in vitro
【摘要】:正AIM:Cyr61 is a secreted matrix protein belonging to the emerging CCN family.Targeted knockout of Cyr61 gene in mice results in embryonic lethality due to placental vascular insufficiency and compromised vessel integrity.Cyr61 is able to stimulate neovascularization in both rat cornea and rabbit ischemic hindlimb in vivo,be rapidly induced by vascular endothelial cell growth factor and promote proliferation,migration and tube formation of vascular endothelial cells(ECs) in vitro.The present study was designed to investi-