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ICJ Inhibits Breast Cancer Metastasis by Selectively Blocking TGF-βinduced Epithelial-Mesenchymal Transition

Qi Li  Yajie Wang  Yujie Li  Xiaoxi Kan  Xiaomin Wang  Ganlin Zhang  Qing Yang  Xi Chen  Xiaogang Weng  Ying Chen  Bingbing Zhou  Yan Guo  Xucen Liu  Xiaoxin Zhu  
【摘要】:正Metastasis represents an unsolved problem which has severely restrained the effectiveness of cancer clinical treatment.Epithelial-mesenchymal transition(EMT),mainly governed by TGF-beta,is the core mechanism controlling metastasis.Notably,TGF-beta plays both prometastatic and cytostasis roles in cancers.Its functional paradox and plasticity provide

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