Urinary 6β-Hydroxycortisol/cortisol ratio as a signal of CYP3A4 activity in chinese children acute lymphoblastic leukemia patients

【摘要】：The present study establish a simple method for determining the concentration of 6β-hydroxycortisol and cortisol in urinary at same time,to determined the urinary 6β-hydroxycortisol/cortisol ratio,a marker for CYP3A activity in 13 Chinese children acute lymphoblastic leukemia patients compare with 114 health children.First-morning urine specimen was collected from each subject for the quantification of urinary concentrations of cortisol and 6β-hydroxycortisol.In this study,the association of the 6β-OHC/cortisol ratio was higher in children acute lymphoblastic leukemia patients than in health children,while the 6β-hydroxycortisol/cortisol ratio is no significant different between subgroups in health children (P).These findings suggest that high CYP3A4 activity may be a risk factor for children acute lymphoblastic leukemia risk.6β-hydroxycortisol/cortisol ratio could be consided as a probe childhood acute lymphoblastic leukemia.