Toll-like receptors—novel potential targets for COPD treatment

【摘要】：COPD is a preventable and treatable disease with some significant extra-pulmonary effects that may contribute to the severity in individual patients.Its pulmonary component is characterized by airflow limitation that is not fully reversible.The airflow limitation is usually progressive and associated with an abnormal inflammatory response of the lung to noxious particles or gases.COPD is also a complex inflammatory disease and particularly sensitive to immune response for the exotic stimulator.While TLRs are a kind of pattern recognition receptors,which are important in the recognition of various pathogens.From the relationship between TLRs and COPD,we can conclude that TLRs are the novel potential therapeutic targets for COPD treatment.