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Altered intrinsic brain activity in patients with vasculogenic erectile dysfunction

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【摘要】:Objectives:To investigate the alteration of the intrinsic spontaneous brain activity of the vasculogenic erectile dysfunction(VED)patients by the fractional amplitude of low-frequency fluctuations(fALFF)index of resting state functional MRI,and to explore if the clinical symptoms of the VED patients is associated with their intrinsic brain activity.Methods:Forty-four VED and 44 healthy controls male subjects were collected by resting state functional magnetic resonance imaging.All participants were asked to complete a series of questionnaires to assess the severity of disease and the status of psychiatry.Intrinsic spontaneous brain activity was calculated and compared between VED and healthy control groups.The relationship between intrinsic spontaneous brain activity and clinical symptoms in VED patients was also investigated.Results:Compared with the healthy control male subjects,VED patients showed abnormal patterns of intrinsic spontaneous brain activity,which was characterized by significant increase fALFF in left lingual gyrus and left posterior cingulate and significant decreased fALFF in more widely brainregions mainly located in frontal lobe,left precentral and some default model network(DMN)areas.Moreover,certain regions of VED patients showed a significant correlation with SDS,NIH-CPIS and PEDT scores.Conclusions:Abnormal intrinsic spontaneous brain activity patterns were observed in VED patients,and these alterations showed a significant correlation with clinical symptoms of VED patients.

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