Genetic polymorphisms of PPAR-γ,HHEX,PTPRD,KCNQ1,and SRR affect therapeutic efficacy of Pioglitazone in Chinese Patients with type 2 diabetes
【摘要】:正This study explored the effects of PPAR-γ,HHEX,PTPRD,KCNQ1,and SRR,polymorphisms on the efficacy of pioglitazone in Chinese patients with type 2 diabetes mellitus(T2DM).67 T2DM patients with various genotypes were randomly selected to undergo an three months pioglitazone treatment.After pioglitazone treatment,decrease in PPG and TG was significantly greater in patients with PPAR-γ rs1801282 CG genotype compared with patients with CC