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Marchantin M:A new inhibitor of proteasome induces autophagic cell death in prostate cancer cells

Hanming Jiang  Jinpeng Sun  Yongqing Liu  Charles YF Young  Guangmin Xi  Huiqing Yuan  Hongxiang Lou  
【摘要】:正We recently reported that marchantin M(Mar M),a cyclic bisbibenzyl compound,was an active agent to induce apoptosis in human prostate cancer,but the molecular mechanisms of action remain largely unknown.Here,we demonstrated that Mar M treatment dramatically enhanced LC3B expression and turnover,suggesting that Mar M induced autophagy.Autophagic cell death was responsible for its cancer cell death-

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