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Injectable and Degradable Polymeric Biomaterials for Regenerative Medicine

【摘要】:Here I present our work on injectable and biodegradable polymeric biomaterials for diverse applications in tissue engineering and regenerative medicine. These photo-crosslinkable biomaterials include copolymers composed of poly(propylene fumarate)(PPF) and poly(-caprolactone)(PCL) or poly(trimethylene carbonate)(PTMC), PCL acrylates(PCLAs) and PTMC fumarates with a wide range of molecular weights, polyethylene glycol diacrylate(PEGDA), and polymer nanocomposites containing hydroxyapatite(HA) nanoparticles and polyhedral oligomeric silsesquioxane(POSS) nanocages. These polymeric biomaterials have been fabricated via photo-crosslinking into different 2 D substrates and 3 D scaffolds with controllable chemistry, topology, and stiffness for different tissue engineering applications,such as bone, cartilage, and peripheral nerve regeneration. We have also surface tethered hydrophilic neutral or cationic polymer chains or Collagen into the polymer networks and fabricated polymer network substrates with microgrooves, micro-pillars, micro-pores, nanowires, or nanopores. Growth factors such as recombinant human bone morphogenetic protein-2(rhBMP-2) have been incorporated into the polymer scaffolds for promoting tissue ingrowth. Besides their practical applications, the networks formed using these polymeric biomaterials also serve as an excellent platform to investigate how material surface characteristics can be used to regulate the behavior and functions of mammalian cells, such as cell adhesion, spreading, phenotype, migration, proliferation, differentiation, and integrin/gene/protein expression.

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