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Association Study of Serotonin Transporter SLC6A4 Gene in Primary Insomnia

Wenjuan Chen  Yuping Xie  Liya Zhou  Jing Wang  Xubin Wang  Xiaoyan Su  Peilin Hui  Wei Ma  Jinfeng Wang  Bin Guo  Jun Yang  Jie Fan  Yuan Zhao  Shangli Zhang  Yu Liu  
【摘要】:The function of 5-hydroxytryptamine(5-HT or serotonin) is to promote arousal,inhibit slow wave sleep(SWS) and rapid-eye-movement sleep(REMS).The solute carrier family 6 member 4(SLC6 A4) gene encodes 5-serotonin transporter(SERT),which uptakes 5-HT from the brain synapses into the presynaptic neuronrapidly.Therefore,it is necessary to explore the association between SLC6 A4 gene polymorphisms and primary insomnia(PI).A total of 129 patients with PI and 149 healthy controls completed the sleep scales,and underwent polysomnography(PSG).The association of single-nucleotide polymorphisms(SNPs) in SLC6 A4 gene with PI was observed in all the subjects.All SNPs were genotyped by SequenomMassArray system.There were different degrees of linkage disequilibrium among 4 loci on SERT gene.There was a complete linkage disequilibrium between rs140700 and rs6352(D'=1.000).A strong linkage disequilibrium was observed between rs2020936 and rs3794808(D'=0.771),rs3794808 and rs6352(D'=0.993),rs2020936 and rs140700(D'=0.803),rs2020936 and rs6352(D'=0.958),and rs140700 and rs3794808(D'=0.958).Thehaplotype CGTT showed significant differences between PI group and control group(p=0.027).All SNPs were distributed in both the groups equally.However,the probability of PI was higher when the genotypes in the four sites were arranged in a combination of CGTT.

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