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Myricetin attenuates MPP~+-induced cytotoxicity by anti-oxidation and c-JNK modulation in MES23.5 cells

【摘要】:正Myricetin is a typical flavonoid existing in many fruits and vegetables,which has a variety of biological functions including anti-oxidation,free radical scavenging and anti-inflammation.Our previous study observed the protective effect of myricetin on dopamine neurons in the 6-OHDA-lesioned rats.However,the mechanisms of this neuroprotective effect of myricetin are unknown.In this study,the effects of myricetin on MPP~+-treated MES23.5 cells were investigated.By MTT assay,we showed that the cell viability decreased after MPP~+ treatment,which could be partly restored by myricetin.The flow cytometry studies showed that myricetin could prevent the MPP~+-induced reduction of the mitochondrial transmembrane potential,the increase of reactive oxide species and the caspase-3 generation in MES23.5 cells.Western blotting studies further demonstrated that the MPP~+-induced phosphorylation of c-Jun N-terminal kinase(JNK) was inhibited by myricetin.These results suggested that the protective effects of myricetin on the toxicity of MPP~+ could be attributed to the anti-oxidative properties and the modulation of c-JNK phosphorylation.

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