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Evoked catecholamine release from sympathetic nerves in rodent cardiac slices

【摘要】:正Neurotransmitter release from presynaptic cells can be recorded by postsynaptic potentials/currents in central nerve system.However,little is known about how to record nerve release in cardiovascular system in fresh tissue or in vivo.We have developed two novel methods for recording catecholamine release induced by nerve action potentials in cardiac slices and in vivo,respectively.Heart beating is regulated by peripheral(vegas and sympathetic) nerves,which innervate and release neurotransmitters in the heart.We are interested in how nerves regulate heart function.In the present study,we demonstrate first recordings from fresh cardiac slices.We have developed a novel method(termed cSEC) to record catecholamine release from rat and mouse sinus atrial nodes (SAN).Using micro carbon fiber electrode(CFE),catecholamine release from sympathetic nerve terminals were recorded as amperometric current(I_(CFE)) following depolarization made by field electric stimulation,high KCl,ACh, or hypoxia.The spatial mapping of evoked catecholamine signals is determined in SAN.

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