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Modulation by oxytocin of ATP-activated currents in rat dorsal root ganglion neurons

【摘要】:正 The modulatory effect of oxytocin(OT)on ATP-activated currents(IATP)was studied infreshly isolated dorsal root ganglion(DRG)neurons of rats using whole cell clamp technique.Inmost of the neurons examined(50/70,71.4%)extracellular application of OT(10~(-9)~10~(-5)mol/L)suppressed IATP while in the rest(20/70,28.6%)no modulatory effect was observed.OTshifted the ATP concentration-response curve downwards with adecrease of 39.8±4.2%in themaximal current response and with no significant change of Kd value.This OT-induced inhibition of

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