收藏本站
收藏 | 手机打开
二维码
手机客户端打开本文

Relevance of SIRS and Sepsis in Pediatric Liver Transplantation

M.Sasse  M.Boehne  I.Forstmeyer  N.Richter  F.Lehner  H.K?ditz  T.Kaussen  K.Seidemann  T.Jack  
【摘要】:Introduction: Liver transplantation(LT) in children has undergone significant changes over the last years. Especially the use of split and living donor transplants even for infants has led to new challenges in pre-and post-operative care. Systemic inflammatory response syndromes(SIRS, sepsis) as well-known complications after LT have not yet been systematically examined in the pediatric population. Methods: We analyzed clinical data of 39 pediatric liver transplant recipients regarding potential risk factors for post-transplant SIRS and sepsis. Secondly, the prognostic impact of SIRS and sepsis on post-transplant clinical course, patient and transplant-survival has been analyzed. Results: 64% of patients developed either SIRS(n = 16, 41%) or sepsis(n = 9, 23%) within 30 days after transplantation. No pre-transplant risk factors for increased susceptibility for SIRS or sepsis could be identified. Secondary closure of the abdomen(p = 0.045) and secondary biliary reconstruction(p = 0.043) were associated with a higher incidence of sepsis and were associated with significantly prolonged mechanical ventilation times in the presence of sepsis(p = 0.001). Patients with sepsis, but not SIRS, stayed significantly longer on PICU(p = 0.021) and suffered from higher mortality(n = 3 versus 0; p = 0.0006). All deaths within 30 days of transplantation were due to septic multiorgan failure. Neither early SIRS nor sepsis were associated with loss of transplant function. Conclusions: SIRS and sepsis are frequent events after pediatric liver transplantation. Sepsis increased length of PICU-stay and mortality significantly and prolonged duration of mechanical ventilation. Secondary biliary reconstruction and closure of the abdomen could be identified as potential risk factors for sepsis.

知网文化
【相似文献】
中国期刊全文数据库 前20条
1 Ioannis A Ziogas;Muhammad H Hayat;Georgios Tsoulfas;;Obstetrical and gynecologic challenges in the liver transplant patient[J];World Journal of Transplantation;2020年11期
2 Cory Higley;Christine C Hsu;Coleman Smith;Sandeep Nadella;Alexander T.Lalos;;Safety and efficacy of sofosbuvir/velpatasvir/voxilaprevir in postliver transplant patients with previous direct-acting antiviral failure: Six case reports[J];World Journal of Hepatology;2020年12期
3 Keshav Anand;Luis Garza;Glenn Halff;Tarunjeet Klair;Francisco Cigarroa;Rajeev Suri;Jorge Lopera;;Direct transmesenteric venous interventions in the acute post liver transplant setting[J];Journal of Interventional Medicine;2021年01期
4 赵丽;;A single-center experience of venous thromboembolism after adult lung transplantation[J];China Medical Abstracts(Internal Medicine);2019年04期
5 Ze-Jia Sun;Xiao-Peng Hu;Bo-Han Fan;Wei Wang;;Epstein-Barr virus-positive post-transplant lymphoproliferative disordepresenting as hematochezia and enterobrosis in renal transplant recipients in China: A report of two cases[J];World Journal of Clinical Cases;2019年24期
6 Anna Mrzljak;Rafaela Novak;Nenad Pandak;Irena Tabain;Lucija Franusic;Ljubo Barbic;Maja Bogdanic;Vladimir Savic;Danko Mikulic;Jadranka Pavicic-Saric;Vladimir Stevanovic;Tatjana Vilibic-Cavlek;;Emerging and neglected zoonoses in transplant population[J];World Journal of Transplantation;2020年03期
7 Maja Cigrovski Berkovic;Lucija Virovic-Jukic;Ines Bilic-Curcic;Anna Mrzljak;;Post-transplant diabetes mellitus and preexisting liver disease-a bidirectional relationship affecting treatment and management[J];World Journal of Gastroenterology;2020年21期
8 Tian Shen;Li Zhuang;Xiao-Dong Sun;Xiao-Sheng Qi;Zhi-Hui Wang;Rui-Dong Li;Wen-Xiu Chang;Jia-Yin Yang;Yang Yang;Shu-Sen Zheng;Xiao Xu;;Expert consensus on management of metabolic disease in Chinese liver transplant recipients[J];World Journal of Gastroenterology;2020年27期
9 Ashwin Rammohan;;Post-transplant immunosuppression and COVID-19:From a double whammy to a mixed blessing[J];World Journal of Transplantation;2020年09期
10 Rossella Gioco;Daniela Corona;Burcin Ekser;Lidia Puzzo;Gaetano Inserra;Flavia Pinto;Chiara Schipa;Francesca Privitera;Pierfrancesco Veroux;Massimiliano Veroux;;Gastrointestinal complications after kidney transplantation[J];World Journal of Gastroenterology;2020年38期
11 Jeevan Prakash Gopal;Vassilios E Papalois;;COVID-19 pandemic: Building organisational flexibility to scale transplant programs[J];World Journal of Transplantation;2020年10期
12 Ashley M Snyder;James Abbott;M Kyle Jensen;Aaron M Secrest;;Fecal microbiota transplant for more than Clostridioides difficile:Dermatology a new frontier[J];World Journal of Dermatology;2020年02期
13 Jordan Sack;Nilofar Najafian;Angela DeLisle;Simona Jakab;;Being accompanied to liver discharge clinic: An easy measure to identify potential liver transplant candidates among those previously considered ineligible[J];World Journal of Hepatology;2019年04期
14 Wisit Cheungpasitporn;Charat Thongprayoon;Michael A Mao;Wonngarm Kittanamongkolchai;Insara J Jaffer Sathick;Tsering Dhondup;Stephen B Erickson;;Incidence of kidney stones in kidney transplant recipients:A systematic review and meta-analysis[J];World Journal of Transplantation;2016年04期
15 Marie Sinclair;Eduard Poltavskiy;Jennifer L Dodge;Jennifer C Lai;;Frailty is independently associated with increased hospitalisation days in patients on the liver transplant waitlist[J];World Journal of Gastroenterology;2017年05期
16 Niraj James Shah;Mark W Russo;;Is it time to rethink combined liver-kidney transplant in hepatitis C patients with advanced fibrosis?[J];World Journal of Hepatology;2017年05期
17 Yolanda Sanchez-Torrijos;Javier Ampuero;Manuel Romero-Gómez;;Cardiovascular assessment in liver transplant for nonalcoholic steatohepatitis patients:What we do,what we should do[J];World Journal of Hepatology;2017年15期
18 Manish Anand;Ekta Nayyar;Beatrice Concepcion;Megha Salani;Heidi Schaefer;;Tuberculosis in kidney transplant recipients:A case series[J];World Journal of Transplantation;2017年03期
19 Hélène Donnadieu-Rigole;Pascal Perney;José Ursic-Bedoya;Stéphanie Faure;Georges-Philippe Pageaux;;Addictive behaviors in liver transplant recipients: The real problem?[J];World Journal of Hepatology;2017年22期
20 Qin-Fen Xie;Ping Chen;Xin-Hua Chen;Ji-Min Liu;Jan Lerut;Shu-Sen Zheng;;Gastrointestinal tract post-transplant lympho proliferative disorder after liver transplantation[J];Hepatobiliary & Pancreatic Diseases International;2017年05期
中国重要会议论文全文数据库 前20条
1 M.Sasse;M.Boehne;I.Forstmeyer;N.Richter;F.Lehner;H.K?ditz;T.Kaussen;K.Seidemann;T.Jack;;Relevance of SIRS and Sepsis in Pediatric Liver Transplantation[A];美国科研出版社2021年论文汇编Ⅰ[C];2021年
2 Li-qing Li;Di-na Chen;Chuan-jiang Li;Qing-ping Li;Yan Chen;Ping Fang;Ping Zheng;Hui-jie Lu;De-mei Ye;Hao-yang Wan;Jie Li;Liang Li;;Impact of UGT1A9, UGT1A8, UGT2B7, ABCC2, ABCG2 and SLCO1B3 genetic polymorphisms on mycophenolic acid metabolism in Chinese renal transplant recipients[A];2018中国遗传学会第十次全国会员代表大会暨学术讨论会论文摘要汇编[C];2018年
3 xia tianyi;Wang Qinghua;Wen Yan;Xiong Xiaojuan;Gao Shouhong;You Chunhua;Tao Xia;Zhang Feng;Chen Wansheng;;18 amino acids assay in human plasma and its application in renal transplant patient by targeted UHPLC-MS/MS method[A];第六届全国治疗药物监测学术年会论文摘要集[C];2016年
4 Chang-Cheng Sheng;Huan-Xi Zhang;Long-Shan Liu;Bi Luo;Qian Fu;Qun Zhao;Jun Li;Yan-Feng Liu;Rong-Hai Deng;Chang-Xi Wang;Zheng Jiao;;Comprehensive external evaluation of published population pharmacokinetics models of mycophenolic mofetil in adult kidney transplant recipients co-administered with tacrolimus[A];2018年中国药理学会定量药理学专业委员会学术年会论文集[C];2018年
5 ;Saliva and plasma concentration of mycophenolic acid in healthy subjects and renal transplant patients[A];2012中国器官移植大会论文汇编[C];2012年
6 张晓鹏;徐涛;刘丽丽;白文俊;王晓峰;;The improvement of Trans-vivo DTH assay and its evaluation in immunological status in heart transplant rat[A];第十五届全国泌尿外科学术会议论文集[C];2008年
7 孙崇然;张建民;赵学群;朱国伟;虞军;;Modulation of major histocompatibility complex by neurotrophins derived from neural stem cell transplant in a rat stroke model[A];2008年浙江省神经外科学学术年会论文汇编[C];2008年
8 ;The regulatory effect of calcineurine inhibitors on peripheral regulatory T cells and inhibitory costimulators in allo-renal recipients[A];中华医学会第九次全国检验医学学术会议暨中国医院协会临床检验管理专业委员会第六届全国临床检验实验室管理学术会议论文汇编[C];2011年
9 Tao Lin;Turun Song;Li Wang;Shaofeng He;Lei Fu;Zhongli Huang;Qiang Wei;;The pre-transplant anemic condition is independent of long term outcome in living related kidney transplantation[A];2013中国器官移植大会论文汇编[C];2013年
10 Rending Wang;Anup Patel;Yanyan Chen;Jianghua Chen;;Multiple relapses of parvovirus B19 infection after renal transplant:a case report and review of the literature[A];2013中国器官移植大会论文汇编[C];2013年
11 ;Induced antigen-specific CD4+CD25highFoxP3+ regulatory T cells following transplant[A];第十五届全国泌尿外科学术会议论文集[C];2008年
12 Chih-Chung Lin;Eric Chang;Wei-chen Lee;;Anesthesia for ABO incompatible living Donor liver transplant[A];2008年中华医学会全国麻醉学术年会论文汇编[C];2008年
13 Chun Wu;Wei Sun;Li Zhang;Mingxing Xie;;Automated left heart chamber volumetric assessment using three-dimensional echocardiography in heart transplant recipients[A];中国超声医学工程学会第十四届全国超声心动图学术会议论文汇编[C];2018年
14 Jun Lee;Hongfeng Huang;Ying Chen;Xiaoyang Lu;;Influence of the ABCB1 haplotype and CYP3A5 genotypes on the sirolimus dose requirements in Chinese renal transplant recipients[A];2013年浙江省医院药学学术年会会议报告与论文汇编[C];2013年
15 屠国伟;;BK virus infection in renal transplant recipients:diagnosis and risk factors analysis[A];第十五届全国泌尿外科学术会议论文集[C];2008年
16 ;Genetic association of tumor necrosis factor pand interleukin-1 gene cluster polymorphism with susceptibility to pneumonia in kidney transplant recipients[A];2012中国器官移植大会论文汇编[C];2012年
17 ;Simultaneous pancreas and kidney transplantation for liver transplant recipients with diabetes and uremia[A];2012中国器官移植大会论文汇编[C];2012年
18 ;Population pharmacokinetics of Cyclosporine and its clinical application[A];中国药理学会临床药理学专业委员会会议暨第十次全国临床药理学学术会议论文集[C];2007年
19 Zhang Zhu-Xu;Kwok Cecilia;Pavlosky Alexander;Lian Dameng;Jiang Jifu;Huang Xuyan;Yin Ziqin;Liu Winnie;Haig Aaron;Jevnikar Anthony;;Necroptosis is Involved in Microvascular Endothelial Cell Death and Chronic Cardiac Allograft Rejection[A];第十一届全国免疫学学术大会分会场交流报告集[C];2016年
20 John D.Brotherton;Dar He;J.Michael Millis;;Three-Year Follow-up Results of the Chinese Subjects Enrolled in the ELADBioartificial Liver Support System Clinical Study Reveal Continued Significant Survival Benefit and Recent ELADClinical Progress in the U.S.and Europe[A];第6届全国疑难及重症肝病大会论文集[C];2011年
中国硕士学位论文全文数据库 前2条
1 薛记莲;肾移植后高同型半胱氨酸血症的临床研究[D];广西医科大学;2016年
2 莫立诗(Mulishi Makenya Maboko);血运重建的移植肾动脉狭窄经皮腔内球囊成形术[D];华中科技大学;2013年
 快捷付款方式  订购知网充值卡  订购热线  帮助中心
  • 400-819-9993
  • 010-62982499
  • 010-62783978