收藏本站
收藏 | 手机打开
二维码
手机客户端打开本文

Anti-lactoferrin antibodies and anti-myeloperoxidase antibodies in autoimmune hepatitis

Liming Tan  Yuhong Zhang  Weihua Peng  Juanjuan Chen  Lan Liu  Hua Li  Feng Ming  Ning Liu  Yuan Huang  
【摘要】:Purpose:The project is aimed to detect anti-lactoferrin antibodies(ALA) and anti-myeloperoxidase antibodies(AMPA) and explore their clinical significance in patients suffered from autoimmune hepatitis(AIH).Methods:59 AIH patients,217 non-AIH patients and 50 healthy controls were enrolled in this study.ALA and AMPA were detected by enzyme linked immunosorbent assay(ELISA).Antineutropil cytoplasmic antibodies(ANCA) and anti-smooth muscle antibodies(ASMA) were examined by indirect immunofluorescence.Antimitochondrial antibody M2 subtype(AMA-M2),anti-liver kidney microsomal antibody type 1(LKM1),anti-liver cytosol antibody type 1(LC1) and anti-soluble liver antigen/liver-pancreas antibodies(SLA/LP) were tested by immunoblot.And the results were retrospectively analyzed.Results:① The positivity for ALA was 18.6%in AIH group,but in non-AIH group,only one patient was positive for ALA who suffered from primary sclerosing cholangitis(PSC);the positivity for AMPA was 59.3%in AIH group,with significant differences(P0.01) compared with any other groups.② The specificity for ALA and AMPA was respectively 99.63%and 97.75%;the sensitivity was respectively 18.64%、59.32%;and the accuracy was respectively 84.97%、90.80%.③ In the consistency analysis between autoantibodies in AIH group,a certain correlation was observed between ALA and SLA/LP,AMPA and ANCA,ASMA in AIH group.Conclusions:ALA and AMPA are associated with AIH,and have high clinical diagnostic value,in addition,co-detection with other relative autoantibodies could play an important role in differential diagnosis of AIH.

知网文化
【相似文献】
中国期刊全文数据库 前1条
1 ;AIH患者:肝脏CT和MRI表现不具特征性[J];现代医院;2009年02期
中国知网广告投放
 快捷付款方式  订购知网充值卡  订购热线  帮助中心
  • 400-819-9993
  • 010-62982499
  • 010-62783978