收藏 | 论文排版

Hearbal decocotosome is a novel form medicine

【摘要】:Traditionally, herbal medicine is consumed by drinking decoctions produced by boiling herbs with water. The functional components of the decoction are heat stable. Small RNAs(sRNAs) were reported as a new class of functional components in decoctions. However, the mechanisms by which sRNAs survive heat treatment of the decoction and enter cells are unclear. Previous studies showed that plant-derived exosomelike nanoparticles(ELNs), which we call botanosomes, could deliver therapeutic reagents in vivo. Here, we report that heat-stable decoctosomes(ELNs) from decoctions have more therapeutic effects than the decoctions in vitro and demonstrate therapeutic efficacy in vivo. Furthermore, sRNAs, such as HJTsRNA-m7 and PGY-sRNA-6, in the decoctosome exhibit potent anti-fibrosis and anti-inflammatory effects, respectively. Decoctosome is comprised of lipids, chemical compounds, proteins, and sRNAs. A medical decoctosome mimic is called bencaosome. A single lipid sphinganine(d22:0) identified in the decoctosomewas mixed and heated with the synthesized sRNAs to form the simplest bencaosome. This simple bencaosome structure was identified by critical micelle concentration(cmc) assay that sRNAs co-assembled with sphinganine(d22:0) to form the lipid layers of vesicles. The heating process facilitates co-assembly of sRNAs and sphinganine(d22:0) until a steady state is reached. The artificially produced sphinganineHJT-sRNA-m7 and sphinganine-PGY-sRNA-6 bencaosomes could ameliorate bleomycin-induced lung fibrosis and poly(I:C)-induced lung inflammation, re-spectively, following oral administration in mice. Our study not only demonstrates that the herbal decoctosome may represent a combinatory remedy in precision medicine but also provides an effective oral delivery route for nucleic acid therapy.

中国期刊全文数据库 前19条
1 李艳玲;梁鹤;;干姜的镇静作用研究(英文)[J];Agricultural Science & Technology;2008年04期
2 Yu-Mei Zhang;Lin Zhu;Xian-Lin Zhao;Huan Chen;Hong-Xin Kang;Jian-Lei Zhao;Mei-Hua Wan;Juan Li;Lv Zhu;Wen-Fu Tang;;Optimal timing for the oral administration of DaCheng-Qi decoction based on the pharmacokinetic and pharmacodynamic targeting of the pancreas in rats with acute pancreatitis[J];World Journal of Gastroenterology;2017年39期
3 Cheng WANG;Xuan XU;Jun-yu LUO;Jing-yu LIU;;Chinese herbal medicine formula SYM prevents brain calcification in a murine model of IBGC[J];中国药理学与毒理学杂志;2015年S1期
4 Yu-Mei Zhang;Hong-Yu Ren;Xian-Lin Zhao;Juan Li;Jun-Yi Li;Fu-Sheng Wu;Hang Su;Wen-Fu Tang;;Pharmacokinetics and pharmacodynamics of Da-Cheng-Qi decoction in the liver of rats with severe acute pancreatitis[J];World Journal of Gastroenterology;2017年08期
5 YANG Xiao-Ni;LI Chang-Sheng;CHEN Chao;TANG Xiao-Yong;CHENG Guang-Qing;LI Xia;;Protective effect of Shouwu Yizhi decoction against vascular dementia by promoting angiogenesis[J];Chinese Journal of Natural Medicines;2017年10期
6 Hui-Lei Wan;Hui-Zhi Chen;Xiu-Qin Shi;;Study on effect of Traditional Chinese Medicine Jianpi Chushi decoction and ointment on chronic eczema[J];Asian Pacific Journal of Tropical Medicine;2016年09期
7 ;Effect of Yiguanjian decoction on cell differentiation and proliferation in CCl_4-treated mice[J];World Journal of Gastroenterology;2012年25期
8 CHENG Xiao;YANG Huan;ZHANG Jun;YANG Yin-lin;WANG Yue-hua;DU Guan-hua;;Xiao-xu-ming decoction inhibits lipopolysaccharide induced neuroinflammation in mice[J];中国药理学与毒理学杂志;2016年10期
9 ;RP-HPLC Determination and Pharmacokinetic Comparison of Cinnamic Acid in Rat Plasma After Administration of Di-Gu-Pi Decoction and Pure Cinnamic Acid[J];Chemical Research in Chinese Universities;2006年01期
10 黄鑫;马世玉;尹鑫;郭力恒;张敏州;;Comparative study of the protective effect between Jiawei huanglian jiedu decoction and Huanglian jiedu decoction in septic rats[J];South China Journal of Cardiology;2018年01期
11 Shi-li Jiang;Xu-dong Hu;Ping Liu;;Immunomodulation and liver protection of Yinchenhao decoction against concanavalin A-induced chronic liver injury in mice[J];Journal of Integrative Medicine;2015年04期
12 Gang Peng;Huanyu Guan;Xiaoming Wang;Yue Shi;;Simultaneous determination of 14 active constituents of Shengjiang Xiexin decoction using ultrafast liquid chromatography coupled with electrospray ionization tandem mass spectrometry[J];Acta Pharmaceutica Sinica B;2017年02期
13 Hai-Xia Deng;Ya-Ya Yu;Ao-Qiang Zhou;Jing-Li Zhu;Li-Na Luo;Wan-Qun Chen;Ling Hu;Geng-Xin Chen;;Yangzheng Sanjie decoction regulates proliferation and apoptosis of gastric cancer cells by enhancing let-7a expression[J];World Journal of Gastroenterology;2017年30期
14 Shan Hui;Yu Yang;Wei-jun Peng;Chen-xia Sheng;Wei Gong;Shuai Chen;Pan-pan Xu;Zhe Wang;;Protective effects of Bushen Tiansui decoction on hippocampal synapses in a rat model of Alzheimer's disease[J];Neural Regeneration Research;2017年10期
15 Yingyi Pan;Zhifeng Chu;Wenjuan Wang;Baican Yang;;Pretreatment with Jieduxiezhuo decoction impedes elevations in serum uric acid levels in mice[J];Journal of Traditional Chinese Medicine;2013年06期
16 ;Effect of Weikangning on gastric cancer cell growth and expression of vascular endothelial growth factor and its receptors KDR and Flt-1[J];World Journal of Gastroenterology;2005年07期
17 Yue-Hua Wang;Ying-Lin Yang;Xiao Cheng;Jun Zhang;Wan Li;Guan-Hua Du;;Xiao-Xu-Ming decoction extract regulates differentially expressed proteins in the hippocampus after chronic cerebral hypoperfusion[J];Neural Regeneration Research;2019年03期
18 Yu Mei;Guo Hangyuan;Ye Lingling;Bian Jiaping;Ma Lijuan;Zheng Chunli;;Effect of Jiawei Shenfu decoction on tumor necrosis factor-alpha and nuclear factor-kappa B in patients who have chronic heart failure with syndromes of deficiency of heart Yang[J];Journal of Traditional Chinese Medicine;2019年03期
19 杨冉;;Clinical observation of Yiqi Yangyin Hexue decoction in treating patients with chronic primary immune thrombocytopenia[J];China Medical Abstracts(Internal Medicine);2019年02期
中国重要会议论文全文数据库 前10条
1 蒋澄宇;;Hearbal decocotosome is a novel form medicine[A];中国生物化学与分子生物学会2019年全国学术会议暨学会成立四十周年论文集[C];2019年
2 ;Pharmacokinetics study of three aromatic acids following oral administration of Shaofu Zhuyu decoction to normal and dysmenorrhea rats[A];中华中医药学会中药分析分会第五届学术交流会论文集[C];2012年
3 Sumei Wang;Zhiwei Peng;Wenjuan Li;Wanyin Wu;;Chinese herbal medicine Fuzheng Kang-Ai decoction enhances the effect of Gefitinib-induced cell apoptosis in lung cancer via mitochondrial pathway[A];第十七届全国中西医结合肿瘤学术大会摘要集[C];2019年
4 YueYang Zhao;LiLing Zeng;Wen Yan;Baiming Zhao;WanYin Wu;Shunqin Long;;Fuzheng Kang''ai decoction for cancer-related fatigue on advanced non-small cell lung cancer patients: a protocol for a randomized controlled trial[A];第十七届全国中西医结合肿瘤学术大会摘要集[C];2019年
5 Jianlei Zhao;Huili Zhu;Zhiyu He;Hanlin Gong;Guangyuan Chen;Wenfu Tang;;Effect of Da-Cheng-Qi decoction on Pancreatitis-associated Intestinal dysmotility in patients and gut motility promotion in rat models:A preliminary study[A];2013医学前沿论坛暨第十三届全国肿瘤药理与化疗学术会议论文集[C];2013年
6 Yunan Tian;Yuke Xiang;Huifeng Zhu;Dong Wan;Shuai Xia;Tao Wang;Xian Yang;;The Effects and Mechanisms of Bazhen Decoction,Siwu Decoction and Sijunzi Decoction on 5-fluorouracil-induced Anemia Mice[A];第十四届全国中药和天然药物学术研讨会论文摘要[C];2014年
7 许良;;Separation and identification of active components from mongolian medicine sendeng-4 decoction[A];中国化学会第十五届全国有机分析及生物分析学术研讨会论文集[C];2009年
8 唐文富;;Effect of Da Cheng Qi decoction on the metabonomics of acute pancreatitis in rats[A];第六届全国中西医结合基础理论研究学术研讨会暨第二届湖南省中西医结合学会肝病专业学术年会论文集[C];2010年
9 胡艳军;代春美;刘义;肖小河;;A comparative study of Traditional Chinese Medicine Mahuangtang and Maxingshigantang by Microcalorimetry[A];中国化学会第十三届全国化学热力学和热分析学术会议论文摘要集[C];2006年
10 ;Absorption of purified ferulic acid and ferulic acid in Rhizoma Chuanxiong decoction in rat body[A];首届中国中西部地区色谱学术交流会暨仪器展览会论文集[C];2006年
中国博士学位论文全文数据库 前1条
1 奚飞飞;多元系统理论视角下《伤寒论》英译的比较研究[D];南京中医药大学;2012年
中国硕士学位论文全文数据库 前2条
1 林淑玲;高职院校教务信息管理系统的分析与设计[D];华北电力大学(河北);2010年
2 高山;国家安全至上—小布什政府全球能源战略浅析[D];外交学院;2011年
 快捷付款方式  订购知网充值卡  订购热线  帮助中心
  • 400-819-9993
  • 010-62982499
  • 010-62783978