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Inhibition of glutathione production by L-buthionine-(S,R)-sulfoximine induces macrophage CD36 expression

Xiaoxiao Yang  Yuanli Chen  Lei Sun  Yajun Duan  Jihong Han  
【摘要】:正Background and purpose:Oxidative stress with high production of reactive oxygen species(ROS)has been implicated in the pathogenesis of atherosclerosis'.Reduced glutathione(GSH)is a cytosolic antioxidant to reduce cellular ROS levels.Glutamate-cysteine ligase(GCL)is the rate-limiting enzyme regulating cellular GSH production.Several studies have demonstrated the importance of GCL in the development of atherosclerosis.

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1 Xiaoxiao Yang;Yuanli Chen;Lei Sun;Yajun Duan;Jihong Han;;Inhibition of glutathione production by L-buthionine-(S,R)-sulfoximine induces macrophage CD36 expression[A];第十二届全国脂质与脂蛋白学术会议论文汇编[C];2014年
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