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Tongxinluo inhibits vascular inflammation and neointimal hyperplasia through blocking positive feedback loop between miR-155 and TNF-α

Ruo-nan Zhang  Bin Zheng  Jin-kun Wen  
【摘要】:正Tongxinluo(TXL),a traditional Chinese medicine,has multiple vasoprotective effects including anti-inflammation.MicroRNA-155(miR-155)is involved in vascular inflammation and atherosclerosis.However,a direct relationship between TXL and miR-155 in the development of vascular inflammation and remodeling had not yet been shown.The objective of the present study was to investigate whether TXL exerts an inhibitory effect on the

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